{"id":"W123540428","doi":"10.1007/978-94-017-9211-0_1","title":"p53 and Hereditary Cancer","year":2014,"lang":"en","type":"review","venue":"Sub-cellular biochemistry/Subcellular biochemistry","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Biology; Carcinogenesis; Cancer syndrome; Li–Fraumeni syndrome; Cancer research; Genetics; Cancer; Penetrance; CDKN2A; Phenotype; Germline; Germline mutation; Single-nucleotide polymorphism; Telomere; Phenocopy; DNA damage; Mutation; Gene; Genotype; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003860316,0.0009432035,0.001107982,0.001998648,0.0002511071,0.0008219664,0.0006782306,0.0009752598,0.003522814],"category_scores_gemma":[0.0005793419,0.000276169,0.0003357197,0.001939149,0.0005574918,0.001125381,0.0008559924,0.001700556,0.001588844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005698053,"about_ca_system_score_gemma":0.0008621131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008994571,"about_ca_topic_score_gemma":0.001870468,"domain_scores_codex":[0.9998683,0.00002201997,0.00001710732,0.00002571778,0.00005193573,0.00001482197],"domain_scores_gemma":[0.9998438,0.00006882233,0.00002591816,0.000006382126,0.00003674839,0.00001835356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009616442,0.00007012335,0.0001967241,0.01015572,0.0000794232,0.0003534577,0.00003913747,0.0003505579,0.001684737,0.003836667,0.05274927,0.9303881],"study_design_scores_gemma":[0.00002865089,0.0000505433,0.0008107477,0.002824631,0.0001540343,0.001801619,0.00005085449,0.0001296287,0.0005029872,0.003368424,0.9902585,0.00001949975],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006728559,0.9984364,0.0001004445,0.0002631744,0.0002359147,0.000002479255,0.00001147195,0.000005856696,0.0008769417],"genre_scores_gemma":[0.0007232153,0.9977905,0.0001433265,0.0002366704,0.0003386796,0.000004232505,0.0000277098,0.000001116467,0.0007345126],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003522814,"threshold_uncertainty_score":0.01178497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01524548939473845,"score_gpt":0.278596877687425,"score_spread":0.2633513882926866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}