{"id":"W123830554","doi":"10.1007/978-1-62703-357-2_20","title":"Thiopurine S-Methyltransferase Pharmacogenetics in Childhood Acute Lymphoblastic Leukemia","year":2013,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McGill University","keywords":"Thiopurine methyltransferase; Pharmacogenetics; Medicine; Pharmacology; Toxicity; Pharmacogenomics; Genotype; Azathioprine; Internal medicine; Biology; Gene; Disease; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002619492,0.0001798779,0.0001752,0.0004078075,0.0001025783,0.0003133935,0.0001156326,0.0002190196,0.0008020545],"category_scores_gemma":[0.0003397501,0.00007988153,0.0001375006,0.0007786112,0.000192915,0.0001468415,0.0001644953,0.0002669699,0.0001987824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004653727,"about_ca_system_score_gemma":0.000354308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001677873,"about_ca_topic_score_gemma":0.002808332,"domain_scores_codex":[0.9998733,0.0000417991,0.00001088914,0.00001901849,0.00004270529,0.00001240879],"domain_scores_gemma":[0.9998759,0.00005789243,0.0000361997,0.00000752554,0.00001235161,0.00001002855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004642766,0.00008262417,0.1061676,0.0008895797,0.0001213068,0.001744191,0.000572562,0.0026763,0.0633383,0.01177743,0.005073092,0.8070928],"study_design_scores_gemma":[0.00007234887,0.0008068802,0.5119371,0.000914078,0.0004723927,0.02248002,0.0005532699,0.004153921,0.1113229,0.0151954,0.3320399,0.00005190812],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.4671923,0.4638495,0.03001554,0.005443498,0.0002641997,0.0001410991,0.001052117,0.000357314,0.0316844],"genre_scores_gemma":[0.6810553,0.2883578,0.02223608,0.0004547767,0.0002001731,0.00007785048,0.0004820075,0.00003920953,0.007096754],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.001677873,"threshold_uncertainty_score":0.003376544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01410420896882659,"score_gpt":0.3752610942479126,"score_spread":0.361156885279086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}