{"id":"W1239088256","doi":"10.1016/j.jtbi.2015.08.015","title":"Neutrophil dynamics during concurrent chemotherapy and G-CSF administration: Mathematical modelling guides dose optimisation to minimise neutropenia","year":2015,"lang":"en","type":"article","venue":"Journal of Theoretical Biology","topic":"Neutropenia and Cancer Infections","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Novartis; Pfizer","keywords":"Neutropenia; Chemotherapy; Medicine; Granulocyte colony-stimulating factor; Dosing; Pharmacokinetics; Regimen; Absolute neutrophil count; Granulocyte; Pharmacodynamics; Pharmacology; Bone marrow; Intensive care medicine; Oncology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003609411,0.000148447,0.0004192816,0.0001103025,0.0000532569,0.00003590451,0.00009686823,0.0001195449,0.0001445911],"category_scores_gemma":[0.0001481182,0.000106892,0.0001005037,0.00010109,0.0002988022,0.00007520334,0.00003949641,0.0002627526,0.00001252486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000141269,"about_ca_system_score_gemma":0.0001616516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000104131,"about_ca_topic_score_gemma":6.042911e-7,"domain_scores_codex":[0.9988401,0.00008649152,0.0005519735,0.0001682516,0.0001511354,0.0002020512],"domain_scores_gemma":[0.9987857,0.00009489666,0.0001648812,0.000145712,0.0003254818,0.0004833631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.005973473,0.0006774174,0.003776031,0.0001358795,0.0002572976,0.0001535905,0.0007320665,0.001808699,0.02037513,0.9588214,0.0005343596,0.006754666],"study_design_scores_gemma":[0.0624444,0.05724176,0.01276129,0.002190572,0.003181305,0.04666233,0.002611486,0.1237679,0.09154484,0.5782012,0.01637867,0.003014285],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9600513,0.0001425479,0.02564701,0.01247853,0.0002713211,0.0002282206,0.000005497387,0.00001554772,0.001160057],"genre_scores_gemma":[0.9917849,0.0001360081,0.007082813,0.0005089055,0.0004016822,0.000006722682,0.000004274654,0.00001701468,0.00005767884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3806202,"threshold_uncertainty_score":0.4358929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03352253901922578,"score_gpt":0.3276888750618738,"score_spread":0.2941663360426481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}