{"id":"W1242386148","doi":"10.1001/jama.2009.954","title":"Genetic Loci Associated With C-Reactive Protein Levels and Risk of Coronary Heart Disease","year":2009,"lang":"en","type":"article","venue":"JAMA","topic":"Adipokines, Inflammation, and Metabolic Diseases","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Mental Health; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Université de Lausanne; Deutsche Herzstiftung; Fondation de France; Bundesministerium für Bildung und Forschung; Thailand Research Fund; Association Diabète Risque Vasculaire; Deutsche Forschungsgemeinschaft; Fédération Française de Cardiologie; Oulun Yliopisto; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Institut National de la Santé et de la Recherche Médicale; British Heart Foundation; Novo Nordisk; National Institute for Health and Care Research; Cancer Research UK; Wellcome Trust; Pfizer; Heart and Stroke Foundation of Canada; Novartis Pharma; European Commission; Sanofi; GlaxoSmithKline; Imperial College London; National Science Foundation; Medical Research Council; Les Laboratories Pierre Fabre; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb; McMaster University","keywords":"Mendelian randomization; Single-nucleotide polymorphism; C-reactive protein; Genome-wide association study; Internal medicine; SNP; Medicine; Context (archaeology); Framingham Risk Score; Allele; Disease; Genetics; Genotype; Biology; Inflammation; Genetic variants; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008726601,0.0001107344,0.0002336163,0.00004992669,0.00004398989,0.000008665316,0.00002968164,0.0000448351,0.00004572815],"category_scores_gemma":[0.0004489315,0.00008300666,0.00004004413,0.0001052167,0.00008291742,0.00009219021,0.000007628621,0.00007973259,0.000003838024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002128839,"about_ca_system_score_gemma":0.000158906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004171453,"about_ca_topic_score_gemma":0.000006811843,"domain_scores_codex":[0.9992641,0.00005815546,0.0001647674,0.0001583658,0.0002177408,0.0001368311],"domain_scores_gemma":[0.9992839,0.00003752114,0.000126707,0.0001684564,0.000170662,0.0002127641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001956059,0.0006422705,0.959716,0.00008828788,0.0002726515,0.000100389,0.0004763151,0.00002553648,0.005667285,0.000200714,0.0009168022,0.02993772],"study_design_scores_gemma":[0.002482264,0.0003160414,0.9940128,0.0001556332,0.0004607694,0.000008883546,0.00004481905,0.00007834237,0.001010065,0.0005293066,0.0008068016,0.00009432181],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972732,0.0008650293,0.00006704443,0.0006183665,0.000009234058,0.000574025,0.00009478204,0.0000367228,0.0004615732],"genre_scores_gemma":[0.9984888,0.00001755624,0.0003883745,0.0003059671,0.0001102318,0.00001908855,0.00003395238,0.0000108331,0.0006252208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03429678,"threshold_uncertainty_score":0.3384914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01157061804704311,"score_gpt":0.2439658441441882,"score_spread":0.2323952260971451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}