{"id":"W1242386148","doi":"10.1001/jama.2009.954","title":"Genetic Loci Associated With C-Reactive Protein Levels and Risk of Coronary Heart Disease","year":2009,"lang":"en","type":"article","venue":"JAMA","topic":"Adipokines, Inflammation, and Metabolic Diseases","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Mental Health; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Université de Lausanne; Deutsche Herzstiftung; Fondation de France; Bundesministerium für Bildung und Forschung; Thailand Research Fund; Association Diabète Risque Vasculaire; Deutsche Forschungsgemeinschaft; Fédération Française de Cardiologie; Oulun Yliopisto; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Institut National de la Santé et de la Recherche Médicale; British Heart Foundation; Novo Nordisk; National Institute for Health and Care Research; Cancer Research UK; Wellcome Trust; Pfizer; Heart and Stroke Foundation of Canada; Novartis Pharma; European Commission; Sanofi; GlaxoSmithKline; Imperial College London; National Science Foundation; Medical Research Council; Les Laboratories Pierre Fabre; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb; McMaster University","keywords":"Mendelian randomization; Single-nucleotide polymorphism; C-reactive protein; Genome-wide association study; Internal medicine; SNP; Medicine; Context (archaeology); Framingham Risk Score; Allele; Disease; Genetics; Genotype; Biology; Inflammation; Genetic variants; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002927237,0.0006378146,0.0006755005,0.0008938871,0.0003794122,0.0006568262,0.0007851297,0.001124441,0.001785572],"category_scores_gemma":[0.00966677,0.0002550404,0.001017078,0.00170979,0.0007365935,0.000185537,0.0003485901,0.0007688865,0.0002015519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003279296,"about_ca_system_score_gemma":0.0006278448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003077259,"about_ca_topic_score_gemma":0.002272358,"domain_scores_codex":[0.9971301,0.001236006,0.0002731316,0.000784407,0.0004087936,0.0001675381],"domain_scores_gemma":[0.9924701,0.003786361,0.002498747,0.0005439057,0.0003721501,0.0003286607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00142839,0.00008369915,0.9888297,0.0001154738,0.002144425,0.0004511658,0.00007675796,0.0005721836,0.003346834,0.0001097515,0.000130748,0.002710966],"study_design_scores_gemma":[0.0002273666,0.0002691353,0.9943737,0.00004285272,0.001422542,0.001116006,0.00004911228,0.00107381,0.0007510582,0.0003720074,0.0002844455,0.00001797548],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954377,0.002162308,0.001126337,0.0003080819,0.00002671738,0.00002276408,0.0005174071,0.00002062397,0.0003780257],"genre_scores_gemma":[0.9984194,0.0003265334,0.0008506188,0.00006088239,0.0000331097,0.00001538567,0.0002390237,0.000004221205,0.00005085808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003077259,"threshold_uncertainty_score":0.01548094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01157061804704311,"score_gpt":0.2439658441441882,"score_spread":0.2323952260971451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}