{"id":"W1245909338","doi":"10.1016/j.cellsig.2015.08.016","title":"Fine-tuned ATP signals are acute mediators in osteocyte mechanotransduction","year":2015,"lang":"en","type":"article","venue":"Cellular Signalling","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"European Commission; Natural Sciences and Engineering Research Council of Canada; University College London; Toyota Foundation; Sundhed og Sygdom, Det Frie Forskningsråd","keywords":"Mechanotransduction; Osteocyte; Cell biology; Purinergic receptor; Mediator; Chemistry; Signal transduction; Purinergic signalling; Intracellular; Adenosine triphosphate; Stimulation; Bone remodeling; Receptor; Osteoblast; Biology; Neuroscience; Biochemistry; Endocrinology; Adenosine receptor; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004533179,0.0002606308,0.0002730182,0.0001246885,0.00006343653,0.00003442763,0.0002448874,0.000260092,0.00005178851],"category_scores_gemma":[0.00005928111,0.0002658012,0.0001297399,0.0002473854,0.00003999296,0.00001297789,0.00006775456,0.0001860107,0.00003688907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003479892,"about_ca_system_score_gemma":0.0001104123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002545296,"about_ca_topic_score_gemma":0.00001360571,"domain_scores_codex":[0.9983456,0.0001046246,0.0003831323,0.0004917511,0.0002793815,0.0003954822],"domain_scores_gemma":[0.999234,0.00001900761,0.0001528265,0.0002656684,0.0001299887,0.0001984819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001485799,0.00004745333,0.0007108984,0.00001754082,0.00006670247,0.0001004605,0.0002883582,0.005955929,0.9912522,0.00002601883,0.001187159,0.000198736],"study_design_scores_gemma":[0.001165987,0.0001733375,0.00001904856,0.00005153091,0.00005457733,0.00001667251,0.0002812924,0.0007685107,0.9896636,0.0002368734,0.007213447,0.0003551075],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9616787,0.006044533,0.0311703,0.0002295622,0.0003675322,0.000213681,0.000009258224,0.00003664868,0.0002497828],"genre_scores_gemma":[0.9974408,0.00008903907,0.0007743079,0.0001514412,0.0007711604,0.00002733632,0.0002032365,0.00005077386,0.0004919172],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03576208,"threshold_uncertainty_score":0.9999794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01982309270552704,"score_gpt":0.2395081048967939,"score_spread":0.2196850121912668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}