{"id":"W1245909338","doi":"10.1016/j.cellsig.2015.08.016","title":"Fine-tuned ATP signals are acute mediators in osteocyte mechanotransduction","year":2015,"lang":"en","type":"article","venue":"Cellular Signalling","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"European Commission; Natural Sciences and Engineering Research Council of Canada; University College London; Toyota Foundation; Sundhed og Sygdom, Det Frie Forskningsråd","keywords":"Mechanotransduction; Osteocyte; Cell biology; Purinergic receptor; Mediator; Chemistry; Signal transduction; Purinergic signalling; Intracellular; Adenosine triphosphate; Stimulation; Bone remodeling; Receptor; Osteoblast; Biology; Neuroscience; Biochemistry; Endocrinology; Adenosine receptor; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002440068,0.0003276655,0.0002520913,0.000243914,0.00033448,0.000863877,0.0002671782,0.0006397707,0.00182526],"category_scores_gemma":[0.0002888528,0.0002160129,0.0001602613,0.0002330745,0.0004651452,0.0007198317,0.0004264135,0.000651624,0.0003196619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003158832,"about_ca_system_score_gemma":0.0001648239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002230571,"about_ca_topic_score_gemma":0.000628698,"domain_scores_codex":[0.999841,0.00002687706,0.00001718687,0.00002366029,0.0000538824,0.00003739358],"domain_scores_gemma":[0.9998559,0.00004836512,0.00003627618,0.00001543063,0.00001537809,0.00002867179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003648248,0.00002732964,0.0004590974,0.0001006794,0.000006234735,0.0004602722,0.00005458299,0.0001425575,0.9896277,0.00199188,0.0000906624,0.006674189],"study_design_scores_gemma":[0.00005910633,0.000465913,0.03186059,0.00004681678,0.0000319116,0.001464018,0.0003496329,0.001254689,0.9554761,0.004381602,0.00458374,0.00002585614],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9450738,0.0268099,0.01765878,0.001050682,0.0002201713,0.0001095661,0.00045132,0.0001386163,0.008487181],"genre_scores_gemma":[0.9907274,0.004407555,0.002650991,0.0001503504,0.00006024936,0.00004029873,0.0001092697,0.00001054708,0.001843378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00182526,"threshold_uncertainty_score":0.006106138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01982309270552704,"score_gpt":0.2395081048967939,"score_spread":0.2196850121912668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}