{"id":"W124742025","doi":"10.1161/circ.124.suppl_21.a17292","title":"Abstract 17292: Long QT Syndrome Variant 3 Patient Derived Induced Pluripotent Stem Cells: Novel and Critical Platform for Drug Screening","year":2011,"lang":"en","type":"article","venue":"Circulation","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Medicine; Induced pluripotent stem cell; Drug; Long QT syndrome; Stem cell; Pharmacology; Intensive care medicine; Internal medicine; Genetics; Embryonic stem cell; QT interval; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004196173,0.0004169545,0.0004011281,0.0003642117,0.0002265354,0.0004477596,0.0003790769,0.000770744,0.003491531],"category_scores_gemma":[0.0002876006,0.0002011234,0.0002352632,0.0002520913,0.0001927164,0.0002444035,0.0003910704,0.0008450328,0.00184026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001770854,"about_ca_system_score_gemma":0.0002362613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002844729,"about_ca_topic_score_gemma":0.0002845445,"domain_scores_codex":[0.9997404,0.00004244575,0.00002520123,0.00004005084,0.0001304825,0.00002145811],"domain_scores_gemma":[0.999905,0.00002259616,0.00001072319,0.00001922145,0.00002234537,0.00002018095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001423186,0.00007674508,0.0006051727,0.00006050874,0.00001470873,0.001364319,0.00004408306,0.0002276266,0.974615,0.00114995,0.002017453,0.01968194],"study_design_scores_gemma":[0.0001899085,0.001166552,0.005936409,0.00003122525,0.0001026171,0.01709403,0.00005363658,0.004211307,0.9110172,0.001022677,0.05914081,0.00003357952],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7972255,0.0145362,0.1360264,0.004785271,0.001177363,0.002183866,0.01512582,0.004245778,0.02469378],"genre_scores_gemma":[0.9080705,0.00567796,0.06035673,0.001185233,0.0002169561,0.0009329524,0.0126193,0.0003329607,0.01060748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003491531,"threshold_uncertainty_score":0.01168031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05495041092068212,"score_gpt":0.267811344370481,"score_spread":0.2128609334497989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}