{"id":"W1249434025","doi":"10.1161/circ.130.suppl_2.15805","title":"Abstract 15805: PCSK9 R46L, Lower LDL and Cardiovascular Disease Risk in Familial Hypercholesterolemia","year":2014,"lang":"en","type":"article","venue":"Circulation","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"PCSK9; Familial hypercholesterolemia; Medicine; Internal medicine; LDL receptor; Apolipoprotein B; Endocrinology; Missense mutation; Kexin; Cohort; Lipoprotein; Mutation; Cholesterol; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004246315,0.000352298,0.0002788763,0.000397547,0.0002263621,0.0002954581,0.0002501503,0.0005836734,0.006520729],"category_scores_gemma":[0.001159267,0.0001031096,0.0002093962,0.0002813484,0.0001700392,0.0001823428,0.0001965359,0.0004067857,0.0006561761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008954663,"about_ca_system_score_gemma":0.0001357849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006683423,"about_ca_topic_score_gemma":0.0003389014,"domain_scores_codex":[0.9998306,0.00005831781,0.00001523259,0.00004327864,0.00003520529,0.00001729882],"domain_scores_gemma":[0.9994832,0.0001679752,0.0001661313,0.00002565159,0.00004949301,0.0001076153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003510321,0.0002799464,0.971994,0.0001165127,0.0002643882,0.001328293,0.0001055786,0.0001268893,0.008773708,0.00009451574,0.001735356,0.01167042],"study_design_scores_gemma":[0.0001104314,0.0005905013,0.9939361,0.00002180391,0.0001501016,0.003099371,0.00004392195,0.0005348171,0.0008034965,0.00009342151,0.0006105169,0.000005406707],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964373,0.001054861,0.0003276099,0.0005184622,0.00005500151,0.00001109315,0.0004697134,0.00002515935,0.001100927],"genre_scores_gemma":[0.9974503,0.0002098017,0.0003738179,0.0001054099,0.0001628719,0.00001312742,0.00034748,0.000005492577,0.001331566],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006520729,"threshold_uncertainty_score":0.02181399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01321070215726696,"score_gpt":0.2349370521811066,"score_spread":0.2217263500238396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}