{"id":"W125784505","doi":"10.1161/circ.116.suppl_16.ii_644-c","title":"Abstract 2892: Inhibition of Toll-like Receptor-2 May Limit Cardiac Dysfunction After a Myocardial Infarction by Reducing Apoptosis via a p38 MAPK-dependent Pathway","year":2007,"lang":"en","type":"article","venue":"Circulation","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital","funders":"","keywords":"Medicine; Myocardial infarction; p38 mitogen-activated protein kinases; Internal medicine; TUNEL assay; Heart failure; Cytokine; TLR2; Cardiology; MAPK/ERK pathway; Cardiac function curve; Apoptosis; Ventricular remodeling; Protein kinase B; Endocrinology; TLR4; Receptor; Phosphorylation; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001667513,0.0008288302,0.0004337717,0.0001731293,0.0001339435,0.0002561136,0.0002524952,0.0004628572,0.00787854],"category_scores_gemma":[0.0001131626,0.0001599173,0.0003346915,0.0001084832,0.0002230269,0.0003125318,0.0002086257,0.001040848,0.001445268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001194156,"about_ca_system_score_gemma":0.0002032323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009353704,"about_ca_topic_score_gemma":0.0001134209,"domain_scores_codex":[0.9999247,0.00001108537,0.000009485634,0.00001446116,0.0000213064,0.00001890218],"domain_scores_gemma":[0.9999338,0.000006877737,0.00002376913,0.000004435602,0.00001228583,0.00001887872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003824477,0.0006972667,0.0004104073,0.0009516772,0.00005190526,0.0002184845,0.00002037258,0.0001283551,0.9787228,0.0002919021,0.001615556,0.0130669],"study_design_scores_gemma":[0.001847848,0.01212884,0.01924152,0.000152265,0.0002151532,0.001697085,0.00007963509,0.00155584,0.9428339,0.0005791099,0.01964557,0.00002318316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9551321,0.02029121,0.007954997,0.002138918,0.001370948,0.0002361682,0.002169066,0.0005337754,0.01017273],"genre_scores_gemma":[0.962037,0.01113077,0.00464504,0.0007462802,0.0004547267,0.0003452547,0.001983012,0.00006509343,0.01859277],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00787854,"threshold_uncertainty_score":0.02635634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01134943925053571,"score_gpt":0.2325564934749602,"score_spread":0.2212070542244245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}