{"id":"W1261754694","doi":"10.1593/neo.91004","title":"Telomere-Centromere-Driven Genomic Instability Contributes to Karyotype Evolution in a Mouse Model of Melanoma","year":2010,"lang":"en","type":"article","venue":"Neoplasia","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba; University of Manitoba","funders":"Canadian Institutes of Health Research; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Telomere; Chromosome instability; Biology; Centromere; Aneuploidy; Genome instability; Telomerase; Chromothripsis; Dicentric chromosome; Molecular biology; Genetics; Cancer research; Cell biology; Karyotype; Chromosome; DNA; DNA damage; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002962679,0.0007155089,0.0002466125,0.00161677,0.0002879078,0.0004277338,0.0003074434,0.0007649423,0.002653928],"category_scores_gemma":[0.0001697432,0.0003604586,0.0003844421,0.0003200092,0.0003567956,0.0003539393,0.000322183,0.001259182,0.00048536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004896701,"about_ca_system_score_gemma":0.0002045718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00078984,"about_ca_topic_score_gemma":0.001202628,"domain_scores_codex":[0.9996691,0.00006771972,0.00003281881,0.00008594785,0.00007389367,0.0000705693],"domain_scores_gemma":[0.9997018,0.00003805499,0.00009851502,0.00004357687,0.00001840644,0.00009961869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000230019,0.0001652277,0.0004016219,0.00001856957,0.000007701288,0.0001407257,0.00002339341,0.0001007609,0.9978216,0.0002434726,0.00003657055,0.0008102976],"study_design_scores_gemma":[0.0001165004,0.002120224,0.01406713,0.00003664058,0.00006406004,0.001830945,0.0000818386,0.004690594,0.9711536,0.0004593259,0.005360266,0.0000189966],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922879,0.001057116,0.003869574,0.0001906853,0.00003646915,0.0000574993,0.0006123182,0.0002129619,0.001675578],"genre_scores_gemma":[0.9858226,0.0009311482,0.002925082,0.00008261651,0.0000149609,0.000141047,0.0006570047,0.0000821923,0.009343372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002653928,"threshold_uncertainty_score":0.008878291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01010560981978621,"score_gpt":0.2032356776459409,"score_spread":0.1931300678261547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}