{"id":"W1263857580","doi":"10.1038/nature14985","title":"The spliceosome is a therapeutic vulnerability in MYC-driven cancer","year":2015,"lang":"en","type":"article","venue":"Nature","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":524,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; National Center for Research Resources; National Institute of General Medical Sciences; National Cancer Institute; National Heart, Lung, and Blood Institute","keywords":"Spliceosome; Biology; Cancer research; RNA; Cancer cell; Transcription (linguistics); Transcription factor; Cell biology; Messenger RNA; Cancer; RNA splicing; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000739709,0.0002880525,0.0003270678,0.0003940449,0.0004012432,0.001003318,0.0002953899,0.0008920221,0.002697288],"category_scores_gemma":[0.0006110578,0.0001612765,0.0002674142,0.0002591027,0.0005733673,0.0007533655,0.0005996184,0.001136709,0.0006030609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005141192,"about_ca_system_score_gemma":0.0003559483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001138817,"about_ca_topic_score_gemma":0.0002106656,"domain_scores_codex":[0.9997286,0.00006137699,0.00002142369,0.00004293361,0.00008677793,0.00005884351],"domain_scores_gemma":[0.9997333,0.00007910658,0.0000753596,0.0000383898,0.00003410112,0.00003984271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001531867,0.0001798956,0.00550089,0.0002576355,0.00009853912,0.003199549,0.0001346426,0.001148581,0.8186027,0.03984228,0.004056928,0.1254465],"study_design_scores_gemma":[0.0001806853,0.003542921,0.0124011,0.0001534505,0.0002439494,0.03975776,0.0004371889,0.005101794,0.7753345,0.0539637,0.1088274,0.00005564636],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8896917,0.03584769,0.02410022,0.01653505,0.0004865138,0.00009785206,0.0005363157,0.0006921627,0.03201263],"genre_scores_gemma":[0.9879107,0.006022341,0.00182777,0.0009805951,0.0001112624,0.00002494901,0.0001268364,0.00004593019,0.002949535],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002697288,"threshold_uncertainty_score":0.009023309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02029958749970593,"score_gpt":0.3433494539294958,"score_spread":0.3230498664297898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}