{"id":"W1267412639","doi":"10.1097/01.fpc.0000189798.11468.6a","title":"P2Y2 receptor polymorphisms and haplotypes in cystic fibrosis and their impact on Ca2+ influx","year":2006,"lang":"en","type":"article","venue":"Pharmacogenetics and Genomics","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Institutes of Health","keywords":"Haplotype; Receptor; Transfection; Biology; Null allele; Cystic fibrosis; Molecular biology; Single-nucleotide polymorphism; Nonsynonymous substitution; Gene; Internal medicine; Endocrinology; Allele; Genotype; Genetics; Medicine; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009411896,0.0002100531,0.0001593094,0.00005874603,0.00006915694,0.00004061231,0.00006213074,0.00009076147,0.00001474014],"category_scores_gemma":[0.000007184346,0.000169947,0.00003493387,0.00004973439,0.00007489957,0.000003094746,0.00009005574,0.00007587351,0.000001628178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009593487,"about_ca_system_score_gemma":0.00002933472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001493551,"about_ca_topic_score_gemma":0.00001494037,"domain_scores_codex":[0.9992315,0.00003152306,0.0001772517,0.0002973419,0.00004403329,0.0002183741],"domain_scores_gemma":[0.9996959,0.00002842525,0.00005116515,0.0001107291,0.00002006269,0.00009374957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002080342,0.00004687891,0.04208067,0.00001950787,0.00004388572,0.000003142624,0.00009752692,0.001232985,0.9502086,0.00003362528,0.001171988,0.004853179],"study_design_scores_gemma":[0.002543243,0.000785367,0.0593011,0.00003733631,0.0000684346,0.00006905843,0.00007299685,0.002076691,0.8849006,0.0006195536,0.04878891,0.0007367437],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9735672,0.02586662,0.0001032517,0.0000976298,0.00004740558,0.0001254004,0.00008957781,0.00000568276,0.00009725886],"genre_scores_gemma":[0.9945141,0.004350074,0.0004623235,0.000216863,0.00026794,0.00001007178,0.00006324171,0.00002757192,0.00008780575],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06530801,"threshold_uncertainty_score":0.6930239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006823673087335146,"score_gpt":0.2417929618242221,"score_spread":0.234969288736887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}