{"id":"W1267482142","doi":"10.1007/978-3-642-27426-8_7","title":"Antisense Technology: From Unique Laboratory Tool to Novel Anticancer Treatments","year":2012,"lang":"en","type":"book-chapter","venue":"RNA technologies","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"","keywords":"Antisense therapy; Oligonucleotide; microRNA; RNA interference; Computational biology; RNA; Cancer; Cancer research; Biology; Medicine; Gene; Locked nucleic acid; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002724677,0.000842719,0.000632942,0.0008246652,0.0002930983,0.001148647,0.0006355797,0.000785395,0.00479855],"category_scores_gemma":[0.0001681872,0.0003536398,0.0003489033,0.0006569833,0.0007482736,0.00154382,0.0006101688,0.001891072,0.00316957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000459404,"about_ca_system_score_gemma":0.0003644188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000140822,"about_ca_topic_score_gemma":0.0003788789,"domain_scores_codex":[0.9998707,0.00001432409,0.000006327691,0.00003028158,0.00006627011,0.00001218484],"domain_scores_gemma":[0.9999435,0.00002974683,0.000005958701,0.0000054648,0.000008557793,0.000006802532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008129383,0.0001111453,0.0001109077,0.001281984,0.00002303039,0.0003228861,0.0002438605,0.0008192627,0.355769,0.153039,0.03585862,0.452339],"study_design_scores_gemma":[0.00001312834,0.0001266385,0.0001358787,0.0001436416,0.00002605094,0.001209433,0.00005463076,0.0006782938,0.09657774,0.03170532,0.8693019,0.0000273706],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"other","genre_scores_codex":[0.01386865,0.5645032,0.2151732,0.005115321,0.00617705,0.0001142317,0.0005105279,0.001446324,0.1930914],"genre_scores_gemma":[0.07946021,0.5281484,0.1170786,0.00425457,0.003307789,0.0003385332,0.0006815984,0.0005719471,0.2661583],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.00479855,"threshold_uncertainty_score":0.01605278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01457320048373987,"score_gpt":0.243698669350276,"score_spread":0.2291254688665362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}