{"id":"W1269071996","doi":"10.1016/j.chemphyslip.2015.07.003","title":"Design, synthesis and antitumor properties of glycosylated antitumor ether lipid (GAEL)- chlorambucil-hybrids","year":2015,"lang":"en","type":"article","venue":"Chemistry and Physics of Lipids","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chlorambucil; Chemistry; DU145; Moiety; Apoptosis; Biochemistry; Cancer research; Stereochemistry; Cancer cell; Cancer; Chemotherapy; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001570908,0.0002251143,0.0001450909,0.000151839,0.0001812858,0.0003029298,0.0002615459,0.0002818647,0.000792802],"category_scores_gemma":[0.0001548164,0.0001258339,0.0001687575,0.0001261471,0.0001471596,0.0002074234,0.0002173491,0.0003435212,0.0002697982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003305681,"about_ca_system_score_gemma":0.0001470123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003007769,"about_ca_topic_score_gemma":0.0004125009,"domain_scores_codex":[0.9999236,0.00001452644,0.000006298777,0.0000148883,0.00001687284,0.00002378601],"domain_scores_gemma":[0.9999324,0.00001342827,0.00002158074,0.000006175141,0.00001276382,0.00001369437],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001368066,0.00002836872,0.00008737198,0.00004264665,0.000006928458,0.00005380291,0.00002658621,0.0005403273,0.9956267,0.0005458539,0.00004703738,0.002857571],"study_design_scores_gemma":[0.00001896913,0.0002641036,0.0002202756,0.000002211834,0.00001212786,0.00005454689,0.000008981942,0.00055881,0.9967973,0.00003448878,0.002022523,0.000005735919],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987075,0.0008979824,0.008769335,0.0001180254,0.00001958727,0.00008995282,0.0001565059,0.00009488452,0.002778718],"genre_scores_gemma":[0.993962,0.0002534073,0.004112428,0.00003641054,0.000003425025,0.00004683105,0.0001069123,0.00001274204,0.001465833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000792802,"threshold_uncertainty_score":0.002652168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03279749773233772,"score_gpt":0.2337031317021077,"score_spread":0.20090563396977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}