{"id":"W1273150541","doi":"10.1593/neo.81384","title":"Recurrent RECQL4 Imbalance and Increased Gene Expression Levels Are Associated with Structural Chromosomal Instability in Sporadic Osteosarcoma","year":2009,"lang":"en","type":"article","venue":"Neoplasia","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Queen's University","funders":"","keywords":"Genome instability; Comparative genomic hybridization; Chromosome instability; Biology; Fluorescence in situ hybridization; Gene; Molecular biology; Copy-number variation; Genetics; In situ hybridization; Cancer research; DNA; Gene expression; Genome; DNA damage; Chromosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001628729,0.0002585371,0.0002569567,0.001079586,0.0001936782,0.0003002002,0.0001343843,0.0002570579,0.001014054],"category_scores_gemma":[0.0005645934,0.0002697784,0.0001396751,0.0004117764,0.0003243697,0.0001417035,0.0001970414,0.0001514134,0.0001943363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001589059,"about_ca_system_score_gemma":0.0001161197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004423751,"about_ca_topic_score_gemma":0.000614592,"domain_scores_codex":[0.9998467,0.00001763333,0.00002007998,0.00003497936,0.00004528893,0.00003530168],"domain_scores_gemma":[0.9995788,0.00007290442,0.0001980508,0.00003695272,0.0000444086,0.00006893886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001219744,0.00007670598,0.1936925,0.00006941257,0.00005403197,0.003376056,0.0002361159,0.0001418758,0.7950652,0.00007600801,0.00006051339,0.005931914],"study_design_scores_gemma":[0.00005528379,0.0006940209,0.8841289,0.000007359316,0.00009249415,0.01704841,0.000256456,0.000812768,0.09568169,0.0002270627,0.0009805962,0.00001502167],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996756,0.0001157313,0.0001011045,0.000004504745,6.60936e-7,0.000001142274,0.00001927725,0.000007312724,0.00007460487],"genre_scores_gemma":[0.9995127,0.00007391862,0.0001461892,0.000003104179,0.000003300545,0.00000290384,0.00007363395,0.000003381787,0.0001809134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001079586,"threshold_uncertainty_score":0.003392339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008582366457045784,"score_gpt":0.2272013494643808,"score_spread":0.218618983007335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}