{"id":"W1273150541","doi":"10.1593/neo.81384","title":"Recurrent RECQL4 Imbalance and Increased Gene Expression Levels Are Associated with Structural Chromosomal Instability in Sporadic Osteosarcoma","year":2009,"lang":"en","type":"article","venue":"Neoplasia","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Queen's University","funders":"","keywords":"Genome instability; Comparative genomic hybridization; Chromosome instability; Biology; Fluorescence in situ hybridization; Gene; Molecular biology; Copy-number variation; Genetics; In situ hybridization; Cancer research; DNA; Gene expression; Genome; DNA damage; Chromosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001646524,0.0002119487,0.0002335767,0.00003938863,0.00006151375,0.00002227899,0.000133949,0.0001958147,0.00001346787],"category_scores_gemma":[0.0001314594,0.000182218,0.00003651569,0.0001234316,0.00005678648,0.00001059781,0.00005748765,0.0001527482,9.875762e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000577972,"about_ca_system_score_gemma":0.00007484545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001439221,"about_ca_topic_score_gemma":0.0001996509,"domain_scores_codex":[0.9986959,0.0001296735,0.0002158432,0.0004931872,0.0001745104,0.0002908931],"domain_scores_gemma":[0.9993448,0.00001426631,0.0001450487,0.0003289408,0.00005394459,0.0001130051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003231397,0.00007320496,0.1336168,0.00001025712,0.00001044926,0.00003788805,0.00006492514,0.000004694743,0.8633652,0.000008500186,0.00003458568,0.002450313],"study_design_scores_gemma":[0.00119085,0.0005128302,0.5397373,0.00007436462,0.000006437495,0.00004372148,0.00002982164,0.00008267792,0.457974,0.0001162953,0.00005826581,0.0001734052],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989809,0.0003822567,0.00001920292,0.00006181057,0.00006627104,0.0002819859,0.00006212244,0.0000313109,0.0001141252],"genre_scores_gemma":[0.9984016,0.00001376125,0.001226666,0.00009821045,0.00005308372,0.00001183165,0.0001562948,0.00001583292,0.00002271103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4061204,"threshold_uncertainty_score":0.7430634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008582366457045784,"score_gpt":0.2272013494643808,"score_spread":0.218618983007335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}