{"id":"W128188881","doi":"10.1096/fasebj.26.1_supplement.761.22","title":"Endothelin‐1 (ET‐1) induces Ca2+‐Calmodulin‐dependent Protein Kinase II α (CaMKII‐α) expression in an ERK1/2‐dependent pathway in vascular smooth muscle cells (VSMC)","year":2012,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Renin-Angiotensin System Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Vascular smooth muscle; Endothelin 1; Endocrinology; Cycloheximide; Internal medicine; Downregulation and upregulation; Chemistry; Signal transduction; Protein kinase C; Receptor; Anisomycin; Cell biology; Kinase; Biology; Medicine; Protein biosynthesis; Smooth muscle; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.004198946,0.0004905724,0.0008299766,0.0004473832,0.0003919596,0.00009243595,0.0004657219,0.0002488395,0.0001585614],"category_scores_gemma":[0.00017275,0.000311664,0.0002820622,0.000318573,0.0001211032,0.0005640812,0.000332429,0.001446695,0.00007648914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004320429,"about_ca_system_score_gemma":0.0002308688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003718259,"about_ca_topic_score_gemma":0.0002682752,"domain_scores_codex":[0.9948746,0.001226321,0.001075925,0.0004651925,0.001328658,0.001029316],"domain_scores_gemma":[0.9978617,0.000118663,0.0004696866,0.0008596166,0.0001923286,0.0004980505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002328905,0.0009122489,0.008388638,0.00003110018,0.00006389274,0.0005033312,0.01039284,0.0002401737,0.9755725,0.00002670573,0.0000597366,0.003575961],"study_design_scores_gemma":[0.005300896,0.0006282758,0.1162568,0.001490698,0.00009199203,0.0002708475,0.003595986,0.0001110469,0.870942,0.0001236356,0.0006675972,0.000520225],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931148,0.003327921,0.0001769917,0.0008152383,0.0006559981,0.001419279,0.00002168377,0.00005002808,0.000418024],"genre_scores_gemma":[0.997198,0.0002052781,0.0008558539,0.0002535184,0.0009247952,0.00009028643,0.000007571288,0.0000834729,0.0003812051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1078681,"threshold_uncertainty_score":0.9999335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02901243808834992,"score_gpt":0.269552114202009,"score_spread":0.2405396761136591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}