{"id":"W129944274","doi":"10.1200/jco.2007.25.18_suppl.7627","title":"Phase II study of the efficacy and safety of intravenous (IV) AVE0005 (VEGF Trap) given every 2 weeks in patients (Pts) with platinum- and erlotinib- resistant adenocarcinoma of the lung (NSCLA)","year":2007,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Internal medicine; Febrile neutropenia; Performance status; Adverse effect; Progressive disease; Nausea; Oncology; Neutropenia; Lung cancer; Carboplatin; Sunitinib; Surgery; Cancer; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001196048,0.001381352,0.001397548,0.0003447618,0.0002778918,0.0006928378,0.0007586462,0.001061205,0.00382923],"category_scores_gemma":[0.0008764931,0.0004925256,0.0008693206,0.0003144535,0.000833403,0.0006623767,0.0002497099,0.002244322,0.0008094871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000774541,"about_ca_system_score_gemma":0.001224872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006709727,"about_ca_topic_score_gemma":0.00150849,"domain_scores_codex":[0.9997088,0.0001547505,0.00001468946,0.00004638298,0.00002404115,0.00005129576],"domain_scores_gemma":[0.9992549,0.0001645657,0.0001684496,0.00004914582,0.00003740336,0.0003255372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.811476,0.06300595,0.004637258,0.00070692,0.0006585189,0.000264323,0.0002467475,0.00321238,0.04406483,0.00021805,0.00238149,0.06912751],"study_design_scores_gemma":[0.452235,0.534784,0.006696513,0.00001903337,0.0001735379,0.0002685022,0.00003591485,0.001412375,0.003053459,0.00008973342,0.001212362,0.00001947594],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995504,0.0008463118,0.0004806659,0.000155033,0.00005480722,0.001458863,0.0005536907,0.00007071604,0.0008759451],"genre_scores_gemma":[0.9921939,0.0007812071,0.001421186,0.0002915905,0.0001216105,0.001663174,0.001506365,0.0000232096,0.001997693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00382923,"threshold_uncertainty_score":0.01281011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05390957801326977,"score_gpt":0.4317827464592963,"score_spread":0.3778731684460265,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}