{"id":"W134805965","doi":"10.1007/978-0-387-71518-6_27","title":"Surrogates for Clinical Development","year":2008,"lang":"en","type":"book-chapter","venue":"Angiogenesis","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Clinical trial; Surrogate endpoint; Pharmacodynamics; Medicine; Drug development; Drug; Angiogenesis; Intensive care medicine; Pharmacology; Computational biology; Internal medicine; Pharmacokinetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007619046,0.0007950137,0.0006956537,0.001284533,0.0005626322,0.003513139,0.0007519202,0.001341127,0.01483532],"category_scores_gemma":[0.01970369,0.0002825384,0.0004414243,0.000879021,0.004941075,0.004640247,0.001844,0.00371239,0.004289413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001904107,"about_ca_system_score_gemma":0.001975031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003762371,"about_ca_topic_score_gemma":0.0005524902,"domain_scores_codex":[0.9960319,0.002442061,0.0001926739,0.0003607058,0.0008790574,0.00009361466],"domain_scores_gemma":[0.9914032,0.006188474,0.0005254094,0.000909631,0.000714232,0.0002590592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001708111,0.00001160431,0.0001004224,0.00008787453,0.000004081654,0.00002574932,0.00006566959,0.0004610518,0.0001104008,0.9217511,0.02154102,0.05582387],"study_design_scores_gemma":[0.000008205796,0.00004107463,0.0001692301,0.0002279571,0.000006120858,0.0001780493,0.00006162146,0.001235547,0.0003082184,0.7717648,0.2259859,0.00001342403],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"review","genre_scores_codex":[0.003343679,0.05394161,0.2847676,0.04355147,0.009504181,0.0002155146,0.000662879,0.0004850175,0.6035281],"genre_scores_gemma":[0.2685903,0.06082321,0.262507,0.01814145,0.009350877,0.001681632,0.001035361,0.0006183931,0.3772518],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.01483532,"threshold_uncertainty_score":0.04962909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1978518514844036,"score_gpt":0.4185228685750589,"score_spread":0.2206710170906553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}