{"id":"W134805965","doi":"10.1007/978-0-387-71518-6_27","title":"Surrogates for Clinical Development","year":2008,"lang":"en","type":"book-chapter","venue":"Angiogenesis","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Clinical trial; Surrogate endpoint; Pharmacodynamics; Medicine; Drug development; Drug; Angiogenesis; Intensive care medicine; Pharmacology; Computational biology; Internal medicine; Pharmacokinetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003951191,0.000241559,0.0009679637,0.0001495138,0.0001219742,0.000004425943,0.0001098448,0.0005779155,0.0006859052],"category_scores_gemma":[0.0001390327,0.000203153,0.0005439512,0.00002127258,0.0001950034,0.00001234193,0.00005652913,0.0001455085,0.0006462681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009525504,"about_ca_system_score_gemma":0.001000188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005858956,"about_ca_topic_score_gemma":0.00001038204,"domain_scores_codex":[0.9984454,0.000015872,0.000571402,0.0003885054,0.0002782271,0.0003006136],"domain_scores_gemma":[0.9984927,0.0005708371,0.0001263897,0.0003273879,0.0002522723,0.0002304552],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001337386,0.0004314665,0.2175028,0.0006722553,0.006503274,0.0005751533,0.0004253291,9.162685e-8,0.00003582814,0.002869649,0.5810829,0.1885638],"study_design_scores_gemma":[0.001104144,0.0003772859,0.02731212,0.0001546102,0.0006130697,0.00008690554,0.000004571481,0.000005523052,0.00007584238,0.0001801747,0.9698746,0.0002111005],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.03264636,0.02204227,0.0005059003,0.001289616,0.0005891802,0.003077035,0.0001076379,0.0001979202,0.9395441],"genre_scores_gemma":[0.002160643,0.01303012,0.01078259,0.0004552959,0.0007953371,0.0001225416,0.0003287466,0.00009482091,0.9722299],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.3887917,"threshold_uncertainty_score":0.8306685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1978518514844036,"score_gpt":0.4185228685750589,"score_spread":0.2206710170906553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}