{"id":"W137748716","doi":"10.1161/circ.118.suppl_18.s_371-a","title":"Abstract 1696: Compound RVX-208 Modulates HDL-C Levels and Function in Non-human Primates and in Early (phase I) Human Trials","year":2008,"lang":"en","type":"article","venue":"Circulation","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Resverlogix (Canada); McGill University","funders":"","keywords":"Pharmacokinetics; Placebo; Medicine; ABCA1; ABCG1; Internal medicine; Endocrinology; Cholesterol; Oral administration; Bioavailability; Pharmacology; Biology; Transporter; Gene; Biochemistry; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007205753,0.0008027075,0.001040706,0.00034499,0.000292809,0.0005214175,0.0004063549,0.0009692637,0.007146888],"category_scores_gemma":[0.0003063047,0.0002317606,0.0003847374,0.0002202337,0.0003990038,0.00042993,0.0001956758,0.001442142,0.001640856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002601554,"about_ca_system_score_gemma":0.0007251423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005133391,"about_ca_topic_score_gemma":0.001047179,"domain_scores_codex":[0.9997893,0.00009590024,0.00001417545,0.00002869967,0.00002800633,0.0000439473],"domain_scores_gemma":[0.9998028,0.00002577458,0.00004421248,0.00001902478,0.00002846297,0.00007977813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2662185,0.04401857,0.003408628,0.002253835,0.0008383129,0.0005443812,0.0002142589,0.0008516151,0.4476398,0.0007459871,0.01560476,0.2176614],"study_design_scores_gemma":[0.1973553,0.6550247,0.01796106,0.0001729531,0.0006226577,0.001068689,0.0001076179,0.0009162938,0.09195819,0.0004699005,0.03427915,0.00006342919],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.976352,0.008072453,0.001633268,0.000818404,0.0002709459,0.002511532,0.002777382,0.0004526422,0.007111383],"genre_scores_gemma":[0.9690494,0.005710884,0.003914611,0.001020374,0.0003770989,0.001912139,0.003548169,0.0000777559,0.01438963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007146888,"threshold_uncertainty_score":0.02390873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08472370641884981,"score_gpt":0.348369855500165,"score_spread":0.2636461490813152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}