{"id":"W140831468","doi":"10.1155/2003/190784","title":"The Role of the Enterohepatic Circulation of Bile Salts and Nuclear Hormone Receptors in the Regulation of Cholesterol Homeostasis: Bile Salts as Ligands for Nuclear Hormone Receptors","year":2003,"lang":"en","type":"review","venue":"Canadian Journal of Gastroenterology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Farnesoid X receptor; Liver X receptor; Nuclear receptor; G protein-coupled bile acid receptor; CYP8B1; Enterohepatic circulation; CYP27A1; Bile acid; Bile Salt Export Pump; Liver receptor homolog-1; Small heterodimer partner; Cholesterol 7 alpha-hydroxylase; Retinoid X receptor; Oxysterol; Cholesterol; FGF19; Internal medicine; Chemistry; Biology; Endocrinology; Receptor; Biochemistry; Transcription factor; Transporter; Medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005316191,0.0004413375,0.0007047551,0.0005415786,0.0003062793,0.001732179,0.0003249203,0.0006893983,0.001122367],"category_scores_gemma":[0.0005117233,0.0002711357,0.0003637999,0.0003638496,0.0008983857,0.001289952,0.0008760961,0.0007960962,0.0004547976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005919664,"about_ca_system_score_gemma":0.0007506033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001186822,"about_ca_topic_score_gemma":0.001030984,"domain_scores_codex":[0.9996767,0.0001093746,0.00003542304,0.00005338726,0.0000731681,0.00005195124],"domain_scores_gemma":[0.9996278,0.00005610666,0.00007117182,0.00003469826,0.0001103378,0.00009989529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.005084042,0.0002356401,0.009279933,0.001974534,0.0002548627,0.003313205,0.0007198932,0.0006340845,0.7655143,0.02648995,0.003296441,0.1832031],"study_design_scores_gemma":[0.00104339,0.005373891,0.08230647,0.0009036147,0.000971803,0.01206679,0.002313312,0.007017163,0.4544003,0.03170101,0.4015428,0.0003595831],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2489615,0.7020002,0.02691928,0.007856359,0.001841158,0.00007598376,0.0002776096,0.0002366283,0.0118313],"genre_scores_gemma":[0.7127529,0.2540059,0.01081228,0.00188086,0.001478712,0.00010151,0.0003258681,0.0001014219,0.01854064],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001732179,"threshold_uncertainty_score":0.004294991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0116125158993491,"score_gpt":0.2340709802238669,"score_spread":0.2224584643245178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}