{"id":"W142138548","doi":"10.1161/circ.124.suppl_21.a16836","title":"Abstract 16836: Pioglitazone Reduces Angiogenesis by Altering Mitochondrial Function and Reducing Hypoxia Inducible Factor-1 Activation","year":2011,"lang":"en","type":"article","venue":"Circulation","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Pioglitazone; Medicine; Angiogenesis; Hypoxia (environmental); Hypoxia-inducible factors; Hypoxia-Inducible Factor 1; Pharmacology; Cancer research; Internal medicine; Cell biology; Endocrinology; Transcription factor; Diabetes mellitus; Biochemistry; Oxygen; Type 2 diabetes; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009082023,0.0005300759,0.0004842023,0.0003137112,0.000170399,0.000271738,0.0002848724,0.0005121683,0.004308001],"category_scores_gemma":[0.00009606255,0.0001232396,0.0002667926,0.0003023605,0.0001836028,0.0001984054,0.0001297677,0.001027786,0.0005847207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002032757,"about_ca_system_score_gemma":0.0004348439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000776711,"about_ca_topic_score_gemma":0.001090519,"domain_scores_codex":[0.9999275,0.000007282445,0.00001034639,0.00001377965,0.00001885562,0.00002225642],"domain_scores_gemma":[0.9999549,0.000004597734,0.00001424872,0.000003984399,0.000006390534,0.00001576077],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01115058,0.001535049,0.0007294499,0.001256829,0.000102811,0.0003125761,0.00004174831,0.0001959543,0.9442842,0.0004532924,0.002439219,0.03749832],"study_design_scores_gemma":[0.003387658,0.01697568,0.01725366,0.0001784853,0.0003785281,0.0009201967,0.0001182878,0.001062426,0.9369212,0.0004132725,0.02236602,0.00002452318],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.969519,0.01773349,0.002252734,0.001264041,0.0006344084,0.0001613131,0.002850221,0.0005258577,0.005058893],"genre_scores_gemma":[0.966338,0.01290767,0.003633928,0.0005793832,0.000208034,0.00033309,0.003065244,0.00004554112,0.01288912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004308001,"threshold_uncertainty_score":0.01441175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02635655285189486,"score_gpt":0.2313872852932772,"score_spread":0.2050307324413823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}