{"id":"W142358202","doi":"10.1021/ja9053338","title":"Enantioselective α-Trifluoromethylation of Aldehydes via Photoredox Organocatalysis","year":2009,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Fluorine in Organic Chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":973,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada","keywords":"Trifluoromethylation; Chemistry; Enantioselective synthesis; Organocatalysis; Trifluoromethyl; Organic chemistry; Photocatalysis; Catalysis; Halide; Combinatorial chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003607566,0.0005875993,0.0002324179,0.0002112936,0.000160183,0.0001566105,0.0004155928,0.0002930991,0.001112569],"category_scores_gemma":[0.000272247,0.0001758877,0.0002958138,0.0001722057,0.0001945909,0.000269639,0.0002193224,0.0005050576,0.000515674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003600097,"about_ca_system_score_gemma":0.0003410374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001557857,"about_ca_topic_score_gemma":0.003099579,"domain_scores_codex":[0.9998077,0.00002757616,0.00001706135,0.00003747826,0.00004319889,0.00006709254],"domain_scores_gemma":[0.9999145,0.00001270963,0.00002829391,0.00001269179,0.00002128575,0.00001042828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007822856,0.00001561608,0.0001133097,0.00006414454,0.00000992998,0.0001813383,0.00005138218,0.0003493937,0.9938428,0.0004870612,0.0001410636,0.004665714],"study_design_scores_gemma":[0.000008697879,0.0001065216,0.0002516969,0.000002728468,0.000007629297,0.0002057648,0.000009973851,0.0002414347,0.9971528,0.00004096367,0.00196475,0.000007087624],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9543005,0.002770253,0.02861373,0.000291611,0.00009143032,0.0001510395,0.0007353372,0.0005323081,0.0125136],"genre_scores_gemma":[0.9819625,0.002101808,0.01124562,0.00007799956,0.00001760246,0.00003378845,0.0005117793,0.00005198022,0.003996942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001557857,"threshold_uncertainty_score":0.003721952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02665893449666629,"score_gpt":0.3676218797620784,"score_spread":0.3409629452654122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}