{"id":"W1427070075","doi":"10.1089/jamp.2014.1150","title":"Considerations for Designing <i>In Vitro</i> Bioequivalence (IVBE) Studies for Pressurized Metered Dose Inhalers (pMDIs) with Spacer or Valved Holding Chamber (S/VHC) Add-on Devices","year":2014,"lang":"en","type":"article","venue":"Journal of Aerosol Medicine and Pulmonary Drug Delivery","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dillon Consulting","funders":"","keywords":"Bioequivalence; Innovator; Product (mathematics); Metered-dose inhaler; Computer science; Mathematics; Medicine; Inhaler; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001363762,0.0003497275,0.00105892,0.000462156,0.0002844844,0.00003273517,0.00007153297,0.0001153924,0.00003686299],"category_scores_gemma":[0.0009417457,0.0002086521,0.0001761762,0.000212492,0.0002939536,0.0003921848,0.00003041855,0.0003226195,0.000001154835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006101366,"about_ca_system_score_gemma":0.0002171886,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000116935,"about_ca_topic_score_gemma":0.00002890438,"domain_scores_codex":[0.9976618,0.0001975231,0.000926536,0.0003526446,0.0004677015,0.0003938401],"domain_scores_gemma":[0.9947956,0.003199675,0.0006706317,0.000203351,0.000868924,0.0002618785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.06862142,0.001094187,0.003076514,0.004494198,0.00241783,0.001746162,0.0113566,0.0009704577,0.8405577,0.00007024033,0.04993782,0.01565687],"study_design_scores_gemma":[0.1722564,0.03699398,0.004395444,0.04697927,0.01342808,0.01062781,0.06951692,0.04849891,0.5576751,0.0007546733,0.03420619,0.00466724],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985542,0.005539029,0.0008611219,0.00573328,0.0005281971,0.001460645,0.00002184111,0.00003190499,0.0002819838],"genre_scores_gemma":[0.9866949,0.001132702,0.006965557,0.003677572,0.000933641,0.00006487929,0.00001093732,0.0000473894,0.0004723773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2828826,"threshold_uncertainty_score":0.8508587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09252051831317591,"score_gpt":0.3324156279557209,"score_spread":0.239895109642545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}