{"id":"W1427070075","doi":"10.1089/jamp.2014.1150","title":"Considerations for Designing <i>In Vitro</i> Bioequivalence (IVBE) Studies for Pressurized Metered Dose Inhalers (pMDIs) with Spacer or Valved Holding Chamber (S/VHC) Add-on Devices","year":2014,"lang":"en","type":"article","venue":"Journal of Aerosol Medicine and Pulmonary Drug Delivery","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dillon Consulting","funders":"","keywords":"Bioequivalence; Innovator; Product (mathematics); Metered-dose inhaler; Computer science; Mathematics; Medicine; Inhaler; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1532242,0.001855722,0.002713794,0.002034284,0.0009790073,0.004946314,0.002504819,0.003747864,0.002152076],"category_scores_gemma":[0.1501422,0.001370335,0.002656588,0.001446565,0.002853305,0.002837856,0.001312773,0.002169599,0.001259968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001473029,"about_ca_system_score_gemma":0.004925286,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000903733,"about_ca_topic_score_gemma":0.00189244,"domain_scores_codex":[0.8528197,0.1188505,0.01044554,0.002383702,0.01483075,0.0006698165],"domain_scores_gemma":[0.7817017,0.1808401,0.01644041,0.006348623,0.01382771,0.0008414083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.01683791,0.003653148,0.02931692,0.02311372,0.00219287,0.002494066,0.002357546,0.03096185,0.3283441,0.02710265,0.01571907,0.5179061],"study_design_scores_gemma":[0.004327704,0.09025292,0.06522708,0.01078901,0.005652799,0.006553167,0.003983976,0.04995648,0.477087,0.03822613,0.2466376,0.001306134],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.1318577,0.02308571,0.7763239,0.0155136,0.001711129,0.02485703,0.002261061,0.0009925416,0.02339734],"genre_scores_gemma":[0.1878973,0.008407211,0.7835954,0.004778857,0.001084569,0.01187183,0.0006345399,0.0002044432,0.00152584],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.1532242,"threshold_uncertainty_score":0.8103365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09252051831317591,"score_gpt":0.3324156279557209,"score_spread":0.239895109642545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}