{"id":"W1439800910","doi":"10.1158/1538-7445.sabcs14-p3-05-04","title":"Abstract P3-05-04: AKT antagonist AZD5363 targets estrogen receptor (ER) function in endocrine resistant breast cancer (BC) and synergises with fulvestrant in vivo","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"PI3K/AKT/mTOR pathway; Fulvestrant; Protein kinase B; Cancer research; Estrogen receptor; Medicine; Pharmacology; Signal transduction; Biology; Internal medicine; Cancer; Cell biology; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001984457,0.0004361635,0.0005112343,0.0003138085,0.0001588778,0.0003096983,0.0003433448,0.0003390923,0.00212572],"category_scores_gemma":[0.00012179,0.000149835,0.0003445605,0.0003069367,0.0002472871,0.000227955,0.000154027,0.001091707,0.0006373765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002567862,"about_ca_system_score_gemma":0.0002721484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007104689,"about_ca_topic_score_gemma":0.001204698,"domain_scores_codex":[0.9998484,0.00003005228,0.00001725823,0.00002241194,0.00004382567,0.00003800261],"domain_scores_gemma":[0.9999049,0.00002049069,0.00002195041,0.0000173735,0.000009526677,0.00002580276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003026151,0.001264242,0.0005725722,0.0001330212,0.00004138087,0.00009487924,0.00002349817,0.0004012468,0.9837442,0.00007742392,0.0003977571,0.01022351],"study_design_scores_gemma":[0.0007976026,0.01760621,0.01215607,0.00001487256,0.0001175507,0.0006099513,0.00004960626,0.001644841,0.9632222,0.00006351069,0.003707474,0.0000101301],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946403,0.002287014,0.0005601287,0.0001752813,0.00005523539,0.00006142275,0.0006574003,0.00009524506,0.001468028],"genre_scores_gemma":[0.9948651,0.001212735,0.0006097553,0.00006062366,0.0000170883,0.00005440493,0.001155621,0.00001403125,0.002010715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00212572,"threshold_uncertainty_score":0.007111192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02229787475557049,"score_gpt":0.3170526272285388,"score_spread":0.2947547524729683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}