{"id":"W1441455127","doi":"10.1371/journal.pone.0131997","title":"Novel Apo E-Derived ABCA1 Agonist Peptide (CS-6253) Promotes Reverse Cholesterol Transport and Induces Formation of preβ-1 HDL In Vitro","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"NIH Clinical Center; Canadian Institutes of Health Research; Geriatric Research Education and Clinical Center; National Cancer Institute; School of Medicine, Stanford University","keywords":"ABCA1; Efflux; Cholesterol; Apolipoprotein B; In vitro; Reverse cholesterol transport; Chemistry; Lipoprotein; Pharmacology; Biology; Biochemistry; Transporter; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001249303,0.0002565865,0.0002217246,0.00009469494,0.00005944157,0.0001672033,0.00009153938,0.0002162401,0.001111072],"category_scores_gemma":[0.00009502003,0.00009440281,0.0001679342,0.00008963804,0.0001157111,0.0001202829,0.0001058497,0.0003476097,0.000310524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00010547,"about_ca_system_score_gemma":0.00008260406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002247314,"about_ca_topic_score_gemma":0.0002296308,"domain_scores_codex":[0.9999261,0.0000146434,0.000009359289,0.0000137208,0.00001932586,0.0000168654],"domain_scores_gemma":[0.9999403,0.00001405411,0.00001597189,0.0000068278,0.000006431318,0.00001643912],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001147011,0.00003799611,0.00005213202,0.00001530725,0.000002355553,0.00003445972,0.000004991587,0.00002890352,0.9990815,0.00001641363,0.00001503335,0.0005961655],"study_design_scores_gemma":[0.00003673353,0.0009525224,0.001402474,0.000003441461,0.00001115238,0.0002260662,0.00001127469,0.0003965422,0.9960693,0.00001718956,0.0008706241,0.000002731522],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977458,0.0005197987,0.0008155366,0.00004525458,0.00001521504,0.00002212978,0.000107502,0.0000304299,0.0006981225],"genre_scores_gemma":[0.9971966,0.0003434114,0.001062772,0.00005425904,0.000006242363,0.00001642951,0.0002666094,0.000009355575,0.001044276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001111072,"threshold_uncertainty_score":0.003716886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07186227726785988,"score_gpt":0.2490845701940824,"score_spread":0.1772222929262225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}