{"id":"W1444325328","doi":"10.1089/nat.2012.0393","title":"The 5′ Binding MID Domain of Human Argonaute2 Tolerates Chemically Modified Nucleotide Analogues","year":2013,"lang":"en","type":"article","venue":"Nucleic Acid Therapeutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Gene silencing; Small interfering RNA; RNA interference; RNA-induced silencing complex; Argonaute; Trans-acting siRNA; RNA silencing; RNA; Nucleic acid; Nucleotide; Sense strand; Biology; Cell biology; Chemistry; Molecular biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001149199,0.0002789121,0.0001714033,0.00006837265,0.0001357559,0.0002129948,0.0002785566,0.0002476941,0.0008204526],"category_scores_gemma":[0.0002204672,0.0001510676,0.0001410514,0.00007401693,0.0001461321,0.0001833725,0.000165104,0.0002681401,0.0003563007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002865381,"about_ca_system_score_gemma":0.0001509802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005206351,"about_ca_topic_score_gemma":0.0006663488,"domain_scores_codex":[0.9998505,0.00002887367,0.000008909333,0.00004550922,0.00004497799,0.00002122785],"domain_scores_gemma":[0.9998988,0.00002847212,0.00002889981,0.00001231797,0.000009759776,0.00002173651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005626219,0.00000661715,0.0001209615,0.00001348092,0.000002633685,0.00001692241,0.000005534681,0.00007719035,0.9990147,0.00009111132,0.00001418377,0.0005803937],"study_design_scores_gemma":[0.000003311399,0.00006220908,0.000999787,0.000001332359,0.000002584948,0.00008736134,0.00000524336,0.0005033177,0.9966396,0.00001863256,0.001673241,0.000003253938],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924851,0.0008882055,0.004573992,0.0000341513,0.00001200634,0.00001355585,0.0001121914,0.00006073555,0.001820176],"genre_scores_gemma":[0.993912,0.000235397,0.003204471,0.00003397246,0.000003682529,0.00002502585,0.0003634857,0.00001503258,0.002206894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008204526,"threshold_uncertainty_score":0.002744734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01813118927636766,"score_gpt":0.2537911190448029,"score_spread":0.2356599297684353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}