{"id":"W1444325328","doi":"10.1089/nat.2012.0393","title":"The 5′ Binding MID Domain of Human Argonaute2 Tolerates Chemically Modified Nucleotide Analogues","year":2013,"lang":"en","type":"article","venue":"Nucleic Acid Therapeutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Gene silencing; Small interfering RNA; RNA interference; RNA-induced silencing complex; Argonaute; Trans-acting siRNA; RNA silencing; RNA; Nucleic acid; Nucleotide; Sense strand; Biology; Cell biology; Chemistry; Molecular biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001532913,0.0001914678,0.0001781845,0.00003258505,0.0002043193,0.00007165717,0.0004961365,0.0001625643,0.00004588041],"category_scores_gemma":[0.00001225879,0.000139193,0.000133405,0.00008725025,0.0002343729,0.000008740759,0.0001177311,0.0001267719,0.00005409104],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001276276,"about_ca_system_score_gemma":0.00003018229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002478411,"about_ca_topic_score_gemma":0.00001633955,"domain_scores_codex":[0.9988832,0.00005557191,0.0003302755,0.0002656166,0.0001523998,0.0003128666],"domain_scores_gemma":[0.9991269,0.00002155981,0.0001498646,0.0004799835,0.0001619348,0.00005982669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003501646,0.0000450256,0.0006307359,0.000007083263,0.0001470003,5.421014e-7,0.000124874,0.000007162061,0.9947891,0.0003623792,0.0008199697,0.003031139],"study_design_scores_gemma":[0.0003298031,0.0002694195,0.001493284,0.00001723084,0.0000237214,0.000003841121,0.0003930654,0.000108961,0.990604,0.001744776,0.004814557,0.000197293],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965022,0.0007320662,0.000151858,0.0003317926,0.0001179788,0.0001757508,0.00001220301,0.00001763534,0.001958496],"genre_scores_gemma":[0.9981006,0.0004091393,0.0003280358,0.0004932921,0.000132936,0.0000195672,0.00005962027,0.00003093232,0.0004258738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004185025,"threshold_uncertainty_score":0.5676126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01813118927636766,"score_gpt":0.2537911190448029,"score_spread":0.2356599297684353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}