{"id":"W144797469","doi":"10.1182/blood.v122.21.1810.1810","title":"Safety Profile and Clinical Response To MEDI-551, a Humanized Monoclonal Anti-CD19, In a Phase 1/2 Study In Adults With Relapsed Or Refractory Advanced B-Cell Malignancies","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Medicine; Neutropenia; Internal medicine; Adverse effect; Refractory (planetary science); Toxicity; Phases of clinical research; Gastroenterology; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001755793,0.0002967314,0.0008464825,0.0003671578,0.00006113449,0.00002857839,0.0002087418,0.0001754637,0.0002576532],"category_scores_gemma":[0.00196347,0.0002084885,0.00005233979,0.0006686355,0.0001785845,0.0001889344,0.0001932059,0.0005618394,0.00008359527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001439971,"about_ca_system_score_gemma":0.004794793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009079758,"about_ca_topic_score_gemma":0.001244242,"domain_scores_codex":[0.9963403,0.000566695,0.0009601135,0.0008084999,0.0006832188,0.0006411244],"domain_scores_gemma":[0.9974113,0.001153277,0.0001397337,0.00066752,0.000202746,0.0004254417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.60345,0.09703947,0.1690065,0.001161891,0.0004780678,0.01858774,0.0222584,0.000010614,0.07339534,0.00000798765,0.001140862,0.01346315],"study_design_scores_gemma":[0.6698607,0.02208805,0.2964875,0.00139297,0.0001249294,0.0002303974,0.0049998,0.0009198128,0.003032715,0.000004422742,0.0004192792,0.0004394748],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939656,0.0002063696,0.000003645536,0.0003745562,0.00004431744,0.005171407,0.00001577579,0.00005889345,0.0001594655],"genre_scores_gemma":[0.995307,0.0001131197,0.002451346,0.0001820152,0.00006908063,0.0005570101,0.0000152016,0.00005759879,0.001247648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.127481,"threshold_uncertainty_score":0.8505757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02333358448421981,"score_gpt":0.3469080447660509,"score_spread":0.3235744602818311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}