{"id":"W144797469","doi":"10.1182/blood.v122.21.1810.1810","title":"Safety Profile and Clinical Response To MEDI-551, a Humanized Monoclonal Anti-CD19, In a Phase 1/2 Study In Adults With Relapsed Or Refractory Advanced B-Cell Malignancies","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Medicine; Neutropenia; Internal medicine; Adverse effect; Refractory (planetary science); Toxicity; Phases of clinical research; Gastroenterology; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001511304,0.00084651,0.001149581,0.0002804135,0.0002813592,0.0005805392,0.000479091,0.0006596926,0.001367501],"category_scores_gemma":[0.0006253342,0.0003082099,0.0007840258,0.0002283952,0.0004826956,0.0004779422,0.0002315608,0.001427781,0.0003277399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005957255,"about_ca_system_score_gemma":0.00067141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004376889,"about_ca_topic_score_gemma":0.001060425,"domain_scores_codex":[0.9996779,0.000166189,0.00002256568,0.00005433878,0.0000339638,0.00004510445],"domain_scores_gemma":[0.9995738,0.00007822433,0.0001100481,0.00002935945,0.00002719021,0.0001814027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4774918,0.05777483,0.03762385,0.001198311,0.00228011,0.0007411645,0.0006034889,0.005043673,0.2318682,0.0003039489,0.003856275,0.1812143],"study_design_scores_gemma":[0.1767133,0.7519339,0.04794043,0.00004766072,0.001065914,0.00075233,0.0000854119,0.001927521,0.01584013,0.0001340522,0.003523145,0.00003629919],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963793,0.001752436,0.0003403375,0.000109184,0.00001913666,0.0004756842,0.0003920783,0.00003892488,0.00049293],"genre_scores_gemma":[0.9959233,0.001094059,0.0007738816,0.0003563223,0.00006063747,0.0004485774,0.0008589636,0.000009670337,0.0004746362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001511304,"threshold_uncertainty_score":0.007992625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02333358448421981,"score_gpt":0.3469080447660509,"score_spread":0.3235744602818311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}