{"id":"W1455575505","doi":"10.1016/j.mimet.2015.08.004","title":"Application of protein misfolding cyclic amplification to detection of prions in anaerobic digestate","year":2015,"lang":"en","type":"article","venue":"Journal of Microbiological Methods","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Provincial Laboratory of Public Health; University of Guelph; Agriculture and Agri-Food Canada; Canadian Food Inspection Agency; Agriculture Food and Rural Development; University of Alberta","funders":"Alberta Prion Research Institute; PrioNet Canada","keywords":"Digestate; Bioreporter; Prion protein; Bioassay; Chemistry; Biology; Anaerobic digestion; Biochemistry; Reporter gene; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008594209,0.0006388358,0.0002489585,0.0004351097,0.000380761,0.0003203004,0.0003995874,0.0005456954,0.0007892716],"category_scores_gemma":[0.0007129292,0.0003092713,0.0002398688,0.000300437,0.000495599,0.0002598694,0.0003572495,0.000943376,0.0002081576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003425269,"about_ca_system_score_gemma":0.0006667122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001195461,"about_ca_topic_score_gemma":0.002088657,"domain_scores_codex":[0.9995024,0.0001583819,0.0000248334,0.0001174603,0.00009813262,0.00009870703],"domain_scores_gemma":[0.9992619,0.0003765773,0.00008727094,0.00005883226,0.0001098849,0.0001054621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008932487,0.00002458977,0.0001991007,0.00002621747,0.0000023747,0.0000189425,0.00002838363,0.00003371765,0.9979234,0.00004768516,0.00001178278,0.00159452],"study_design_scores_gemma":[0.000007778253,0.0003487268,0.001735887,0.000009607453,0.000009738101,0.0001004496,0.00002967704,0.001617376,0.9956793,0.00006653826,0.0003875814,0.000007348924],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9233696,0.002145211,0.07163098,0.0001911353,0.0000862787,0.0001739815,0.0001462628,0.0001536721,0.002102827],"genre_scores_gemma":[0.9284288,0.001027097,0.06748755,0.00012625,0.00003025594,0.0001730973,0.0003068819,0.00002865602,0.00239138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001195461,"threshold_uncertainty_score":0.004545152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.034809871522405,"score_gpt":0.3620947360260475,"score_spread":0.3272848645036425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}