{"id":"W1455755008","doi":"","title":"AEG35156, a XIAP antisense oligonucleotide, suppresses XIAP levels in targeted tissues isolated from pre-clinical models and from patients","year":2006,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Aegera Therapeutics (Canada)","funders":"","keywords":"XIAP; Cancer research; Docetaxel; Inhibitor of apoptosis; Apoptosis; Cancer; In vivo; Medicine; Chemistry; Pharmacology; Biology; Caspase; Internal medicine; Programmed cell death; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000129489,0.0003010908,0.0002040819,0.000261891,0.000106558,0.0001755518,0.0001350024,0.0001825235,0.002085708],"category_scores_gemma":[0.0001327452,0.0001300852,0.0001291411,0.0001428722,0.0001582507,0.0001053062,0.0000922951,0.0008066961,0.0006152792],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002456633,"about_ca_system_score_gemma":0.0001915876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006835766,"about_ca_topic_score_gemma":0.001377274,"domain_scores_codex":[0.9999278,0.00001070131,0.000006199848,0.00001607496,0.00002139083,0.00001797901],"domain_scores_gemma":[0.9999431,0.00001120876,0.00001074276,0.000009202751,0.00000620635,0.00001952028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003282808,0.0001191745,0.0003835991,0.0000276348,0.000006937726,0.0001035725,0.00001925772,0.00007403438,0.9950321,0.00007931209,0.0004669475,0.003359192],"study_design_scores_gemma":[0.0002468401,0.00559422,0.01953104,0.0000139891,0.0000583905,0.004020242,0.00005638123,0.001344445,0.957719,0.00009549434,0.01131024,0.000009796924],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908507,0.002417351,0.001497599,0.0002418866,0.00007801834,0.0001135136,0.0006523606,0.0001384484,0.00400999],"genre_scores_gemma":[0.9912667,0.00130082,0.001562099,0.0001692875,0.00002954833,0.00006361008,0.001784492,0.00001732058,0.003806124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002085708,"threshold_uncertainty_score":0.006977439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05452248551189761,"score_gpt":0.3748736452327271,"score_spread":0.3203511597208295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}