{"id":"W1464936406","doi":"10.1056/nejmoa1505270","title":"Palbociclib in Hormone-Receptor–Positive Advanced Breast Cancer","year":2015,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":1586,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre","funders":"","keywords":"Fulvestrant; Palbociclib; Medicine; Internal medicine; Oncology; Breast cancer; Hazard ratio; Exemestane; Clinical endpoint; Neutropenia; Placebo; Cancer; Metastatic breast cancer; Clinical trial; Estrogen receptor; Confidence interval; Chemotherapy; Tamoxifen; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001884273,0.0004617159,0.0009867615,0.0002986626,0.0001404227,0.000399872,0.0004911614,0.0003944036,0.002440599],"category_scores_gemma":[0.001046032,0.0001348965,0.0005456429,0.0004478287,0.0003695629,0.0002548472,0.0002369457,0.001343132,0.0003426367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007387105,"about_ca_system_score_gemma":0.0008084495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008887127,"about_ca_topic_score_gemma":0.001633444,"domain_scores_codex":[0.9995535,0.0002611357,0.00002398864,0.00004192064,0.00007298626,0.00004644508],"domain_scores_gemma":[0.9993764,0.0002965547,0.0001292112,0.00002355735,0.00004372876,0.0001305692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3075694,0.006162496,0.03248898,0.003805821,0.002071054,0.0007932136,0.0001888438,0.008326773,0.02524329,0.0008229252,0.009927599,0.6025996],"study_design_scores_gemma":[0.4779657,0.2767511,0.155647,0.001089875,0.00472255,0.003101252,0.0001980109,0.009795113,0.0134307,0.002642588,0.05458042,0.00007582745],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9238576,0.06402872,0.001131754,0.002328543,0.0002646635,0.00097919,0.0007130063,0.0001054862,0.006591238],"genre_scores_gemma":[0.9801615,0.0160187,0.0007974224,0.0008348558,0.0002611175,0.0003820375,0.0006428174,0.00001307567,0.0008884715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002440599,"threshold_uncertainty_score":0.009965062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01997212785007568,"score_gpt":0.3116514899941887,"score_spread":0.2916793621441131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}