{"id":"W1465670628","doi":"10.1016/j.ygeno.2015.09.003","title":"The effect of 5-fluorouracil/leucovorin chemotherapy on CpG methylation, or the confounding role of leukocyte heterogeneity: An illustration","year":2015,"lang":"en","type":"article","venue":"Genomics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; University of Toronto; Toronto General Hospital; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Ottawa Hospital; University of Ottawa; Ontario Institute for Cancer Research","funders":"National Cancer Institute; Canadian Institutes of Health Research; Génome Québec; Seventh Framework Programme; McGill University","keywords":"Methylation; Confounding; Biology; Fluorouracil; CpG site; DNA methylation; Internal medicine; Colorectal cancer; Oncology; Epigenome; Chemotherapy; Immunology; Gastroenterology; Cancer; Cancer research; Genetics; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001062399,0.0001207357,0.0001366855,0.00002108297,0.0001050698,0.00002697937,0.0002022668,0.0001032714,0.000002209822],"category_scores_gemma":[0.0001299737,0.00006363555,0.00006607903,0.0000660228,0.00008568617,0.000005044962,0.00003328867,0.00005959846,0.000001609983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003054224,"about_ca_system_score_gemma":0.00009435301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002951849,"about_ca_topic_score_gemma":0.00008603482,"domain_scores_codex":[0.9990636,0.0002148218,0.0002675906,0.0001703692,0.0001503086,0.0001333465],"domain_scores_gemma":[0.9991022,0.00008817868,0.000223187,0.0004192099,0.0001168311,0.00005035521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007265389,0.00001840768,0.003784012,0.000007315835,0.00006499526,1.220066e-7,0.0002548106,0.004161497,0.9412935,0.0002789146,0.00001939883,0.04939053],"study_design_scores_gemma":[0.0005686794,0.001576936,0.0009698887,0.000003568475,0.00002039938,0.000001111373,0.0001562366,0.0008849539,0.9745928,0.0003227866,0.02082011,0.00008252376],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965717,0.0009114339,0.001710741,0.00006652107,0.0001313604,0.000282439,0.000007263889,0.000004286502,0.0003142166],"genre_scores_gemma":[0.9990577,0.0003594853,0.0001915619,0.00002811343,0.0001794062,0.00001768973,0.00004773497,0.00001804244,0.0001002678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04930801,"threshold_uncertainty_score":0.2594982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02594171527614554,"score_gpt":0.3011286106222955,"score_spread":0.2751868953461499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}