{"id":"W1465685963","doi":"10.1096/fasebj.29.1_supplement.714.11","title":"Scorpion Toxin BeKm‐1 Blocks Low K <sup>+</sup> ‐induced Endocytosis of Cell‐surface Human Ether‐a‐go‐go Related Gene (hERG) Channels","year":2015,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"hERG; Internalization; Chemistry; Patch clamp; Potassium channel; Endocytosis; Biophysics; Ion channel; HEK 293 cells; Voltage clamp; Membrane potential; Pharmacology; Biochemistry; Cell; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000155787,0.0003345643,0.0003204198,0.000136256,0.00009736409,0.0002118585,0.000259263,0.0003468766,0.0006307263],"category_scores_gemma":[0.0001598491,0.0001188126,0.000331716,0.0001169182,0.0003114117,0.0002330501,0.0001882876,0.0006442871,0.0002481589],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003640279,"about_ca_system_score_gemma":0.0002710936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000614022,"about_ca_topic_score_gemma":0.000676741,"domain_scores_codex":[0.9998534,0.00002478585,0.00001413389,0.00001815351,0.00003523821,0.00005416804],"domain_scores_gemma":[0.9999169,0.00003411415,0.00001903514,0.000008531824,0.000006444164,0.00001498145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002235775,0.0000646242,0.0001285576,0.0000389034,0.000008223846,0.00007254056,0.00001701854,0.0001297186,0.9983589,0.0001111744,0.00004820924,0.000798495],"study_design_scores_gemma":[0.00005627781,0.0006912387,0.003836604,0.00000587261,0.00001884168,0.000193147,0.00002308822,0.002071417,0.9923717,0.00004396367,0.0006834253,0.000004512039],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976268,0.0007154267,0.0007182887,0.00006630566,0.0000159426,0.00001735958,0.0001208573,0.00004602136,0.0006729945],"genre_scores_gemma":[0.9968503,0.0006455468,0.0009503949,0.00005294069,0.00001064184,0.00002639003,0.0003109495,0.00001572203,0.001137075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006307263,"threshold_uncertainty_score":0.002641261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02436703985254783,"score_gpt":0.2622559190697045,"score_spread":0.2378888792171567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}