{"id":"W1466412209","doi":"10.1016/j.pharmthera.2015.07.005","title":"Changes in mu-opioid receptor expression and function in the mesolimbic system after long-term access to a palatable diet","year":2015,"lang":"en","type":"review","venue":"Pharmacology & Therapeutics","topic":"Neuroendocrine regulation and behavior","field":"Psychology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; University of Calgary","funders":"","keywords":"μ-opioid receptor; Receptor; Opioid; Offspring; Mesolimbic pathway; Nucleus accumbens; Opioid receptor; Obesity; Endocrinology; Reward system; Brain stimulation reward; Internal medicine; Biology; Psychology; Neuroscience; Medicine; Ventral tegmental area; Dopamine; Pregnancy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004295545,0.0004635151,0.0009899917,0.0004831332,0.00005619162,0.00007375165,0.0005246667,0.0002627664,0.0006981944],"category_scores_gemma":[0.000001412496,0.0003202791,0.0001026944,0.0005314615,0.00006786443,0.0001012942,0.000210391,0.0006620514,0.0001586262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00017288,"about_ca_system_score_gemma":0.00006784698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001202911,"about_ca_topic_score_gemma":0.0001052711,"domain_scores_codex":[0.996629,0.001462711,0.0005400381,0.0006287066,0.000209446,0.0005301087],"domain_scores_gemma":[0.9989781,0.0001984618,0.0002519466,0.000405196,0.00005334156,0.0001129431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00149344,0.0008777076,0.01176121,0.005509472,0.0002998301,0.000448461,0.002117791,0.000001049847,0.0004092912,0.00001873727,0.01073658,0.9663264],"study_design_scores_gemma":[0.001043183,0.0003020247,0.006425944,0.001174146,0.001215535,0.0001053688,0.00009302078,0.000001678217,0.0000316932,0.000002459209,0.9892842,0.0003208026],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02623347,0.9659314,0.000008327254,0.0008795898,0.003396718,0.003278729,0.00006020532,0.00007706343,0.0001345256],"genre_scores_gemma":[0.01752474,0.9690273,0.00001321989,0.004569951,0.0008204122,0.006038837,0.0001521648,0.0001429102,0.001710429],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9785476,"threshold_uncertainty_score":0.9999249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1553380522545795,"score_gpt":0.4515210133134145,"score_spread":0.296182961058835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}