{"id":"W146956941","doi":"10.1007/3-540-26670-4_8","title":"Protein Tyrosine Phosphatases as Therapeutic Targets","year":2005,"lang":"en","type":"book-chapter","venue":"Handbook of experimental pharmacology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Protein tyrosine phosphatase; Biology; Cdc25; Signal transduction; Kinase; Cell signaling; Phosphatase; Insulin receptor; Function (biology); Phosphorylation; Cell biology; Gene; Cell cycle; Genetics; Insulin; Insulin resistance; Cyclin-dependent kinase 1","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001036495,0.0006899855,0.0006420009,0.0001093139,0.0001019383,0.00001625812,0.0005332615,0.0005342932,0.006524974],"category_scores_gemma":[0.00001173096,0.000714613,0.0003053501,0.00002358337,0.0005732633,0.00001124994,0.000435305,0.000272771,0.0002530936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007947338,"about_ca_system_score_gemma":0.000232275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000202489,"about_ca_topic_score_gemma":0.000003149032,"domain_scores_codex":[0.9977735,0.00004856026,0.0006023953,0.000811175,0.0002935161,0.0004708364],"domain_scores_gemma":[0.9986879,0.00001780028,0.0004824353,0.0005108363,0.0001120704,0.0001889402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001011157,0.0002437095,0.00000120915,0.00004575636,0.0004177939,0.00003703154,0.00002532715,0.000004231875,0.9525432,0.0106833,0.0326271,0.002360166],"study_design_scores_gemma":[0.001287613,0.001080865,4.294809e-7,0.0001130853,0.00008868374,0.0000316773,0.000006127486,0.000001805029,0.6451968,0.0003433506,0.3514284,0.0004211836],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"other","genre_scores_codex":[0.001046306,0.9417893,0.0001183558,0.0001141195,0.0006389177,0.002200292,0.0007619343,0.00005882517,0.05327198],"genre_scores_gemma":[0.3718574,0.0180037,0.004735451,0.006905363,0.004714932,0.001508417,0.007906987,0.0008344038,0.5835333],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.9237856,"threshold_uncertainty_score":0.9995305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01450275260896828,"score_gpt":0.2901988882674598,"score_spread":0.2756961356584915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}