{"id":"W1470905765","doi":"10.1016/j.cbpc.2015.08.002","title":"The p53 inhibitor, pifithrin-α, disrupts microtubule organization, arrests growth, and induces polyploidy in the rainbow trout gill cell line, RTgill-W1","year":2015,"lang":"en","type":"article","venue":"Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Environment and Climate Change Canada; University of Waterloo","funders":"National Centre for Biological Sciences; Natural Sciences and Engineering Research Council of Canada","keywords":"Rainbow trout; Microtubule; Biology; Cell biology; Mitosis; Fetal bovine serum; Tubulin; Cell culture; Mitotic index; Fish <Actinopterygii>; Genetics; Fishery","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003479702,0.0003883696,0.0006127688,0.00007211156,0.0003754142,0.00002584126,0.0002914138,0.0004629886,0.00003549406],"category_scores_gemma":[0.0001492793,0.0002686006,0.00005718749,0.0004126706,0.001742116,0.00006141178,0.000217478,0.0008522694,0.00001757065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000079636,"about_ca_system_score_gemma":0.0003186415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001432392,"about_ca_topic_score_gemma":0.00001438369,"domain_scores_codex":[0.9976634,0.0005296583,0.0004664545,0.0006681106,0.0001277673,0.000544598],"domain_scores_gemma":[0.9984941,0.0005174407,0.0002457653,0.0002956151,0.0002236909,0.0002233533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005975095,0.0003996705,0.001772087,0.00004920507,0.0001246175,0.00004191176,0.001468602,0.00002413793,0.9819064,0.0001196279,0.01343517,0.00006105039],"study_design_scores_gemma":[0.004666446,0.0007085613,0.008039311,0.00002055665,0.0001635795,0.0002580211,0.001032148,0.00008556829,0.9744105,0.0002889304,0.01003141,0.0002949974],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888553,0.004387213,0.00001106323,0.004460534,0.0008066988,0.0007312103,0.00002526859,0.00004390681,0.0006788208],"genre_scores_gemma":[0.9952187,0.0004943128,0.00003479353,0.003103016,0.0007087094,0.000160931,0.0001172373,0.00002536073,0.0001369369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007495944,"threshold_uncertainty_score":0.9999766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03084495001887917,"score_gpt":0.3084555062823355,"score_spread":0.2776105562634563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}