{"id":"W1472422037","doi":"10.1016/j.matbio.2015.06.005","title":"Biophysical analysis of a lethal laminin alpha-1 mutation reveals altered self-interaction","year":2015,"lang":"en","type":"article","venue":"Matrix Biology","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; Multiple Sclerosis Society of Canada","keywords":"Laminin; Mutant; Zebrafish; Basement membrane; Heterotrimeric G protein; Cell biology; Mutation; Biophysics; Biology; Chemistry; Extracellular matrix; Genetics; Gene; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000263465,0.00009277982,0.0003992336,0.0004895468,0.00001282581,0.000005160537,0.00007256136,0.000116679,0.0001351879],"category_scores_gemma":[0.000166957,0.0000769285,0.00014115,0.0007062878,0.00006305925,0.00002838327,0.00004204774,0.0001354907,0.0001076798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008727954,"about_ca_system_score_gemma":0.00006112034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006738669,"about_ca_topic_score_gemma":0.000007281104,"domain_scores_codex":[0.9989773,0.0001742426,0.0002920408,0.0002106138,0.0001651116,0.0001807027],"domain_scores_gemma":[0.9992281,0.0001269838,0.00009071578,0.0002293156,0.0001973983,0.0001275286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005538762,0.0003574319,0.02007645,0.00007348966,0.00122474,0.00007005299,0.000502698,0.00008067823,0.9702944,0.0002445043,0.003120827,0.00340084],"study_design_scores_gemma":[0.01203357,0.009930254,0.2872827,0.0001105883,0.007139992,0.0005509397,0.002175252,0.2246468,0.4273605,0.001310805,0.02643377,0.001024862],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976994,0.00008497175,0.0006334847,0.0003362442,0.0001167781,0.0001801634,0.00001563575,0.00005322134,0.0008801247],"genre_scores_gemma":[0.9978881,0.00001826007,0.00123459,0.00005023385,0.0001075945,0.0000121922,0.0002340313,0.000010467,0.0004445294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5429339,"threshold_uncertainty_score":0.3137053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0492623376778656,"score_gpt":0.3995463253683271,"score_spread":0.3502839876904615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}