{"id":"W1479455333","doi":"10.1371/journal.pone.0133735","title":"Anticancer Activity of Apaziquone in Oral Cancer Cells and Xenograft Model: Implications for Oral Cancer Therapy","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research; Spectrum Pharmaceuticals","keywords":"In vivo; Apoptosis; Cancer research; Cancer; Poly ADP ribose polymerase; Cancer cell; Medicine; In vitro; Pharmacology; Caspase 3; Biology; Programmed cell death; Internal medicine; Polymerase; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001242272,0.000120458,0.0002253362,0.00003628787,0.00002711141,0.000009899079,0.0001003408,0.00009847696,0.0000062617],"category_scores_gemma":[0.00000562955,0.0001161013,0.00003983493,0.00008199237,0.00005998061,0.000006148386,0.00004113825,0.00005543265,1.733045e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003610616,"about_ca_system_score_gemma":0.0002069856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005313737,"about_ca_topic_score_gemma":0.00142137,"domain_scores_codex":[0.9992879,0.0000192576,0.0001340034,0.0002605979,0.00009256473,0.0002056509],"domain_scores_gemma":[0.9994548,0.000007381147,0.00007739134,0.0002170474,0.0001605264,0.00008283503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003506248,0.000458985,0.001730696,0.00003182203,0.0001455983,4.907543e-8,0.0001018698,0.0002428375,0.9882992,0.0001235518,0.0001302204,0.008384566],"study_design_scores_gemma":[0.001561584,0.0002780613,0.0008548335,0.00002914108,0.00005638283,1.720364e-7,0.0000152501,0.003323021,0.9917049,0.0007854239,0.001230031,0.0001611704],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925118,0.002597701,0.003267294,0.0007090013,0.00004088438,0.0004822399,0.0003349592,0.000007126776,0.00004897768],"genre_scores_gemma":[0.9897289,0.006335287,0.002854524,0.0003192142,0.00007497094,0.0004310093,0.00001773878,0.00002731163,0.000211094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008223396,"threshold_uncertainty_score":0.4734474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.131020307439442,"score_gpt":0.3381228682888172,"score_spread":0.2071025608493752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}