{"id":"W1479455333","doi":"10.1371/journal.pone.0133735","title":"Anticancer Activity of Apaziquone in Oral Cancer Cells and Xenograft Model: Implications for Oral Cancer Therapy","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research; Spectrum Pharmaceuticals","keywords":"In vivo; Apoptosis; Cancer research; Cancer; Poly ADP ribose polymerase; Cancer cell; Medicine; In vitro; Pharmacology; Caspase 3; Biology; Programmed cell death; Internal medicine; Polymerase; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004071999,0.0005745041,0.000612912,0.0004047303,0.0002180079,0.0003613042,0.0004241459,0.0004313541,0.001683229],"category_scores_gemma":[0.0001086438,0.0001882278,0.0003340944,0.0003035187,0.0003008957,0.0004831934,0.0001907666,0.0009720896,0.0002235626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000362345,"about_ca_system_score_gemma":0.0003604658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00133569,"about_ca_topic_score_gemma":0.002185118,"domain_scores_codex":[0.9998549,0.00003917489,0.0000164507,0.00002564775,0.00003530348,0.00002854119],"domain_scores_gemma":[0.9998857,0.00003019354,0.00002165848,0.00002433077,0.00001906072,0.00001904878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002184612,0.0001857094,0.0001848826,0.0001115996,0.000006665069,0.00005177889,0.00001928248,0.0001880412,0.9963222,0.0001539184,0.0000552391,0.002502351],"study_design_scores_gemma":[0.00006068134,0.002904673,0.002965524,0.00001941678,0.00005277484,0.0003049256,0.00005880837,0.001385485,0.9893455,0.0001119785,0.002777477,0.00001275474],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9797828,0.008716299,0.007690772,0.0004140761,0.00008874766,0.0001830019,0.0009434053,0.0001486618,0.002032277],"genre_scores_gemma":[0.9845398,0.006386994,0.005162536,0.00005604914,0.00001178173,0.0001426056,0.0007076412,0.00001572019,0.002976868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001683229,"threshold_uncertainty_score":0.00563097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.131020307439442,"score_gpt":0.3381228682888172,"score_spread":0.2071025608493752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}