{"id":"W1479688650","doi":"10.4049/jimmunol.175.12.8280","title":"IL-18 Induces Monocyte Chemotactic Protein-1 Production in Macrophages through the Phosphatidylinositol 3-Kinase/Akt and MEK/ERK1/2 Pathways","year":2005,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Calgary","funders":"","keywords":"PI3K/AKT/mTOR pathway; Signal transduction; Protein kinase B; Cell biology; Autocrine signalling; Proinflammatory cytokine; Monocyte; Phosphatidylinositol; Kinase; MAPK/ERK pathway; Chemotaxis; Biology; Chemistry; Cancer research; Inflammation; Immunology; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005067897,0.0001593523,0.0001948151,0.00004464945,0.0001612048,0.00002139205,0.0003421483,0.0001377149,0.00001777709],"category_scores_gemma":[0.0001573218,0.00009408325,0.00006585943,0.0001101484,0.0002517338,0.00003122523,0.0001132083,0.0003788435,0.000006089068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002429757,"about_ca_system_score_gemma":0.0000828807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003541037,"about_ca_topic_score_gemma":0.00001768603,"domain_scores_codex":[0.998898,0.0002241648,0.0003928272,0.0001388994,0.0001023619,0.0002438048],"domain_scores_gemma":[0.999188,0.0000213224,0.0003538683,0.0003094027,0.0001125207,0.00001486188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005301273,0.00008799762,0.00007895805,0.000008451915,0.000130901,0.000003673533,0.001209992,0.0000827171,0.9824237,0.00003759458,0.0002741548,0.01513171],"study_design_scores_gemma":[0.0007988339,0.0005712116,0.002685455,0.00003007726,0.00003759007,0.0002844301,0.001492027,0.000005137094,0.9807518,0.0003028347,0.01292579,0.0001148346],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9715808,0.02409687,0.00002680783,0.003539665,0.0002039828,0.0002681798,0.000001401363,0.000003716299,0.0002785746],"genre_scores_gemma":[0.9943956,0.004675609,0.0001820977,0.000226506,0.0002505113,0.0000106822,0.000002965893,0.00001613761,0.0002399081],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02281477,"threshold_uncertainty_score":0.3836603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01195431915540372,"score_gpt":0.236234883873959,"score_spread":0.2242805647185553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}