{"id":"W1479848891","doi":"10.4049/jimmunol.1400913","title":"Identification of the Inflammasome <i>Nlrp1b</i> as the Candidate Gene Conferring Diabetes Risk at the <i>Idd4.1</i> Locus in the Nonobese Diabetic Mouse","year":2015,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research","keywords":"Biology; Nod; NOD mice; Congenic; Genetics; Inflammasome; Locus (genetics); Gene; Candidate gene; Exon; Allele; Innate immune system; Autoimmunity; Immune system; Molecular biology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002118128,0.0004554007,0.0003150735,0.0008304442,0.000206852,0.000296234,0.000308797,0.0004547234,0.002150883],"category_scores_gemma":[0.0002497687,0.0003075861,0.000469209,0.000232806,0.0003262522,0.0001072876,0.0003472609,0.0007884105,0.0003226945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002764688,"about_ca_system_score_gemma":0.0001866263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004098118,"about_ca_topic_score_gemma":0.0004366406,"domain_scores_codex":[0.9997385,0.00004314625,0.00002062309,0.000102029,0.00005387991,0.00004176163],"domain_scores_gemma":[0.9997267,0.00004297023,0.0001208751,0.00002467592,0.00001532265,0.00006945128],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004265219,0.00004511808,0.002639126,0.00003256149,0.00001427933,0.0001709535,0.00002051032,0.00007113148,0.9946007,0.0001460778,0.00004139135,0.001791819],"study_design_scores_gemma":[0.000347609,0.001020321,0.144363,0.00008170543,0.0002926787,0.004315252,0.0001424431,0.003311484,0.8370927,0.0005750823,0.008415334,0.00004242882],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935005,0.0005654091,0.004268013,0.000133124,0.00002590569,0.00002686354,0.000653428,0.0001079909,0.0007186461],"genre_scores_gemma":[0.989075,0.0005068824,0.0059606,0.0001150132,0.00002090636,0.0000634122,0.001335707,0.00007743461,0.002845113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002150883,"threshold_uncertainty_score":0.007195473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005024416940853828,"score_gpt":0.2086069591712539,"score_spread":0.2035825422304001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}