{"id":"W1479907458","doi":"10.1002/cncr.28152","title":"Molecular pathogenesis of endometrial cancers in patients with Lynch syndrome","year":2013,"lang":"en","type":"article","venue":"Cancer","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Cancer Institute","keywords":"PTEN; Medicine; Atypical hyperplasia; Tensin; Endometrial hyperplasia; Lynch syndrome; Endometrial cancer; KRAS; Carcinogenesis; Cancer research; Carcinoma; Hyperplasia; Internal medicine; Pathology; Cancer; Gastroenterology; PI3K/AKT/mTOR pathway; Biology; DNA mismatch repair; Genetics; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00005130065,0.0001471206,0.0003639491,0.0001943678,0.00001137797,0.000005347468,0.00009190596,0.00008028667,0.001259771],"category_scores_gemma":[0.00006608266,0.0001156666,0.00005484614,0.0005731033,0.00008457261,0.00004479159,0.00002817105,0.0001032796,0.00001223208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005188856,"about_ca_system_score_gemma":0.00035106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001555197,"about_ca_topic_score_gemma":0.00008886502,"domain_scores_codex":[0.9988351,0.00002586936,0.0002415089,0.0002525504,0.0003874477,0.0002574634],"domain_scores_gemma":[0.9992928,0.00003450673,0.00009430009,0.0002592553,0.0002098738,0.0001092913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004600298,0.00008518572,0.9738867,0.0001038318,0.00009509658,0.00001781643,0.0001026544,0.0005214377,0.01398777,0.00000464364,0.0002323795,0.01050246],"study_design_scores_gemma":[0.004622958,0.0008028567,0.9793515,0.0001652786,0.0000598167,0.000002837681,0.00002226152,0.0000312735,0.01460112,0.00001307956,0.0001839894,0.0001429901],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973356,0.0008135325,0.0000171044,0.00006977507,0.0003274957,0.0008963185,0.0000265455,0.00001362012,0.0005000088],"genre_scores_gemma":[0.9989139,0.00004492543,0.0003944223,0.0001781012,0.00003177395,0.0003313023,0.000008044599,0.00003136855,0.0000661552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01035947,"threshold_uncertainty_score":0.9996532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007949158607479063,"score_gpt":0.2346539720000814,"score_spread":0.2267048133926023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}