{"id":"W1479909557","doi":"10.3109/17435390.2014.996192","title":"Intratracheally instilled titanium dioxide nanoparticles translocate to heart and liver and activate complement cascade in the heart of C57BL/6 mice","year":2015,"lang":"en","type":"article","venue":"Nanotoxicology","topic":"Mechanical Circulatory Support Devices","field":"Engineering","cited_by":144,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"Health Canada; BD; Agilent Technologies","keywords":"Titanium dioxide; Materials science; Complement (music); Cascade; Nanoparticle; Cell biology; Complement system; Biophysics; Nanotechnology; Medicine; Chemistry; Immunology; Biology; Biochemistry; Chromatography","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002982961,0.0006815714,0.0003427524,0.0004990401,0.0002113521,0.0003317597,0.0003085377,0.000703437,0.001869934],"category_scores_gemma":[0.0001176835,0.0003270363,0.0004787782,0.0001780286,0.0005587083,0.0003386585,0.0002047928,0.001301822,0.0003733739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003557286,"about_ca_system_score_gemma":0.0002779907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001155707,"about_ca_topic_score_gemma":0.002057582,"domain_scores_codex":[0.999739,0.0000173707,0.00001546344,0.0001029613,0.00006380025,0.00006139038],"domain_scores_gemma":[0.9997886,0.00002783109,0.00007436077,0.00002015129,0.00002359857,0.00006545489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000242159,0.00005876904,0.0001026949,0.00002534248,0.000004129289,0.00003074671,0.00001755285,0.00003659399,0.99901,0.0000296888,0.00003337328,0.0004090094],"study_design_scores_gemma":[0.0000418231,0.001500135,0.005310769,0.00001130804,0.00003079801,0.0001234319,0.00005311111,0.000850916,0.9912958,0.00005459944,0.0007163893,0.00001078659],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909675,0.001016409,0.004714345,0.0003173546,0.0000996614,0.00007904222,0.0009884033,0.0001705071,0.001646817],"genre_scores_gemma":[0.9788817,0.001198202,0.006548636,0.0003394964,0.00004096283,0.0002438601,0.0009011806,0.00007679446,0.01176922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001869934,"threshold_uncertainty_score":0.006255567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03605101538475097,"score_gpt":0.2639265136202341,"score_spread":0.2278754982354831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}