{"id":"W1479963652","doi":"10.1074/jbc.m707773200","title":"The 44-kDa Pim-1 Kinase Phosphorylates BCRP/ABCG2 and Thereby Promotes Its Multimerization and Drug-resistant Activity in Human Prostate Cancer Cells","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital","funders":"National Institute of Environmental Health Sciences; National Cancer Institute","keywords":"Abcg2; Prostate cancer; Cancer research; Cancer cell; Cancer; Pharmacology; Efflux; Docetaxel; Multiple drug resistance; Kinase; Chemistry; Phosphorylation; Biology; Drug resistance; ATP-binding cassette transporter; Transporter; Cell biology; Medicine; Internal medicine; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001022794,0.0002938756,0.000246498,0.0002854523,0.0002683864,0.0002702477,0.0001313542,0.0001633729,0.001805784],"category_scores_gemma":[0.00009978034,0.0001741306,0.0002687687,0.0002608265,0.0001048881,0.0001232371,0.000165869,0.0004898562,0.0006907241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003949474,"about_ca_system_score_gemma":0.0002101202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001292051,"about_ca_topic_score_gemma":0.001003212,"domain_scores_codex":[0.9998627,0.00002147576,0.000006450732,0.0000185714,0.00005316026,0.00003767169],"domain_scores_gemma":[0.9999681,0.000003451164,0.000007043765,0.000004699415,0.000005448885,0.00001122382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007042322,0.00002209076,0.0002285181,0.00004588294,0.000008052188,0.00008675274,0.0000135093,0.00006566325,0.9976405,0.00008105222,0.0001691117,0.00156841],"study_design_scores_gemma":[0.00002623407,0.0001765016,0.01412946,0.000004061719,0.00002686645,0.0008962497,0.0000288352,0.001490868,0.9754192,0.00006525475,0.007726538,0.000009829272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885817,0.005054789,0.002055746,0.0003431564,0.00004677448,0.00005850609,0.001048663,0.000156202,0.002654472],"genre_scores_gemma":[0.9920329,0.001686782,0.001554486,0.00006676033,0.0000189805,0.00004958856,0.001073981,0.00001117101,0.003505368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001805784,"threshold_uncertainty_score":0.006040931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01500380939620572,"score_gpt":0.2813073119601263,"score_spread":0.2663035025639206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}