{"id":"W1479969203","doi":"10.18632/aging.100300","title":"The Werner syndrome helicase protein is required for cell proliferation, immortalization, and tumorigenesis in Scaffold Attachment Factor B1 deficient mice","year":2011,"lang":"en","type":"article","venue":"Aging","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"Canadian Institutes of Health Research; U.S. Public Health Service","keywords":"Helicase; Carcinogenesis; Molecular biology; Biology; Cell cycle; RecQ helicase; Mutant; Telomere; Cell biology; Cell; Gene; Genetics; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001701173,0.0006988611,0.0003346427,0.0008214524,0.0002161041,0.0003388058,0.0002555604,0.000503879,0.001840861],"category_scores_gemma":[0.0001918706,0.0003194998,0.0002832472,0.0001989732,0.0003276767,0.0002243518,0.000283147,0.0005727933,0.0007734166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002510271,"about_ca_system_score_gemma":0.0002324436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000564467,"about_ca_topic_score_gemma":0.0006776565,"domain_scores_codex":[0.9997967,0.00003381086,0.00002890513,0.00004881512,0.00005554377,0.00003622639],"domain_scores_gemma":[0.9996206,0.00004680803,0.0001518853,0.00002995942,0.000016829,0.0001339473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006601071,0.00001276804,0.000195835,0.00001169878,0.00000451963,0.000116958,0.00001046346,0.0000272846,0.9990228,0.00008440491,0.00002063122,0.0004267023],"study_design_scores_gemma":[0.00007141164,0.0003163445,0.01486648,0.0000208613,0.00004516466,0.002065089,0.00004868054,0.001347546,0.9760434,0.0002234509,0.004936851,0.00001477345],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911702,0.00169255,0.004542991,0.0001244174,0.00003371456,0.00002712782,0.0009754809,0.0003067082,0.001126867],"genre_scores_gemma":[0.9913536,0.001230427,0.002264117,0.0000444119,0.00001581407,0.00005720096,0.001176753,0.00009311109,0.003764543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001840861,"threshold_uncertainty_score":0.006158292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01805900281681601,"score_gpt":0.2460651738141056,"score_spread":0.2280061709972896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}