{"id":"W1480311381","doi":"10.1111/j.1471-4159.2012.07808.x","title":"Constitutively active mutant gives novel insights into the mechanism of bitter taste receptor activation","year":2012,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Biochemical Analysis and Sensing Techniques","field":"Nursing","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital Research Institute of Manitoba; University of Manitoba","funders":"Research Manitoba; Manitoba Health Research Council; Heart and Stroke Foundation of Canada","keywords":"Rhodopsin; Mutant; G protein-coupled receptor; Transmembrane domain; Receptor; Signal transduction; Biology; Agonist; Subfamily; Transmembrane protein; Cell biology; Biochemistry; Genetics; Retinal; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008276839,0.0003496502,0.000249378,0.000153965,0.0001093342,0.0002550089,0.0003534892,0.0004159002,0.00122707],"category_scores_gemma":[0.00009977045,0.0001018197,0.0003907897,0.00008653876,0.0002108776,0.0002179892,0.0001862442,0.0005202703,0.0004346195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002100178,"about_ca_system_score_gemma":0.0001343855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003463899,"about_ca_topic_score_gemma":0.0002406594,"domain_scores_codex":[0.9998931,0.00001217632,0.00001648025,0.00002613506,0.00003082812,0.00002127271],"domain_scores_gemma":[0.9999177,0.00001479849,0.00002055704,0.00001458772,0.000007691639,0.0000246036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002971081,0.000005031484,0.00005823078,0.000006627647,0.000001639203,0.00006103104,0.000005062288,0.00002600209,0.9994388,0.0001014315,0.000008804018,0.0002575754],"study_design_scores_gemma":[0.00001781579,0.000158028,0.002742639,0.000004915231,0.00002006865,0.0007648175,0.00003638052,0.002850991,0.9911677,0.0001998478,0.002025565,0.00001113919],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993385,0.0004763529,0.004550475,0.0001235402,0.00003062285,0.00001104432,0.0003472923,0.0001611477,0.0009145038],"genre_scores_gemma":[0.9943209,0.0004462407,0.003044078,0.00006451473,0.000009023512,0.00001492916,0.0005230942,0.00005203743,0.00152514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00122707,"threshold_uncertainty_score":0.004104972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01677097958635363,"score_gpt":0.2506723772235748,"score_spread":0.2339013976372212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}