{"id":"W1480456069","doi":"10.1038/nri822","title":"T-cell signalling and autoimmunity: molecular mechanisms of disease","year":2002,"lang":"en","type":"review","venue":"Nature reviews. Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":148,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; University of Toronto","funders":"","keywords":"Autoimmunity; Signalling; Autoimmune disease; Biology; Disease; Signalling pathways; Immunology; Cell biology; Neuroscience; Signal transduction; Immune system; Computational biology; Medicine; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"category_scores_codex":[0.0009455658,0.00155903,0.006568959,0.0008176976,0.0003215753,0.00002956023,0.001642225,0.005019163,0.001218574],"category_scores_gemma":[0.0003547496,0.001242737,0.001633074,0.00073536,0.001098622,0.0001150376,0.0009071305,0.005822051,0.001418137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001281073,"about_ca_system_score_gemma":0.0003009941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002541631,"about_ca_topic_score_gemma":0.000001366007,"domain_scores_codex":[0.9918922,0.003055538,0.002420591,0.001344619,0.0001081609,0.00117889],"domain_scores_gemma":[0.9951314,0.0006346818,0.002117781,0.001837134,0.0001875506,0.00009145433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007495191,0.0007844635,5.455316e-7,0.0222372,0.001849552,0.0001032808,0.00007159778,2.255501e-7,0.1318541,0.009170479,0.001912952,0.8319406],"study_design_scores_gemma":[0.0009381236,0.0003714362,6.928252e-7,0.008392158,0.002666061,0.0003595036,0.00001755119,4.541421e-7,0.003246747,0.0008366811,0.9821447,0.001025967],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004253163,0.9944595,0.0002657407,0.00006574173,0.00191275,0.002127188,0.0001524823,0.0001538661,0.0008202514],"genre_scores_gemma":[0.0008449145,0.9938761,0.0003410844,0.0001924424,0.00003968309,0.0002834217,0.0009006857,0.0001777075,0.003343985],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9802317,"threshold_uncertainty_score":0.9997158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01937357663951917,"score_gpt":0.267282229754003,"score_spread":0.2479086531144838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}