{"id":"W1481631662","doi":"10.1096/fasebj.28.1_supplement.1096.6","title":"CORM‐3 derived CO suppresses NLRP3 inflammasome in cardiac fibroblasts and protects cardiomyocytes from apoptosis in mice with sepsis (1096.6)","year":2014,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"","keywords":"Inflammasome; Apoptosis; Cardiac function curve; Sepsis; Medicine; Inflammation; Priming (agriculture); Caspase 1; Chemistry; Cell biology; Immunology; Internal medicine; Biology; Biochemistry; Heart failure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002994873,0.0005973502,0.0005326127,0.0004054765,0.0002111831,0.0002719297,0.0002189081,0.0005984263,0.001329856],"category_scores_gemma":[0.0001811231,0.000171254,0.0005017254,0.000196616,0.0003443875,0.0002320428,0.0002788143,0.00111844,0.0004103986],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002771401,"about_ca_system_score_gemma":0.0003528861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005354239,"about_ca_topic_score_gemma":0.0008643957,"domain_scores_codex":[0.9997142,0.00005000002,0.0000363793,0.00004328772,0.00007141787,0.00008475729],"domain_scores_gemma":[0.9998003,0.00001372844,0.00007069734,0.00002590766,0.00002496351,0.0000644826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006064101,0.0001040233,0.0001996236,0.00007656832,0.000008819117,0.00007431001,0.00001601934,0.00004168509,0.9975818,0.00003769197,0.00009462836,0.001158407],"study_design_scores_gemma":[0.000217531,0.001963037,0.00665936,0.00002317186,0.00004987396,0.0005327342,0.00007658292,0.0007522315,0.9860405,0.00006576304,0.003607699,0.00001152664],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902028,0.003086208,0.003236296,0.0004440625,0.0001663381,0.00008871092,0.0009887159,0.0001989849,0.001587888],"genre_scores_gemma":[0.9923712,0.0009168728,0.002731284,0.0002708996,0.00003969834,0.0001570804,0.0009892164,0.00003722336,0.002486387],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001329856,"threshold_uncertainty_score":0.004448831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00462833861057212,"score_gpt":0.2015564672947774,"score_spread":0.1969281286842053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}