{"id":"W1481651785","doi":"10.3389/fgene.2015.00117","title":"Hippocampal transcriptome-guided genetic analysis of correlated episodic memory phenotypes in Alzheimer's disease","year":2015,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; U.S. National Library of Medicine; IXICO; Servier; Eisai; University of California, San Diego; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; Synarc; University of Southern California; Medpace; Novartis Pharmaceuticals Corporation; Dartmouth College; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Foundation for the National Institutes of Health; Alzheimer's Disease Neuroimaging Initiative; National Center for Advancing Translational Sciences; Meso Scale Diagnostics; Alzheimer's Association; National Science Foundation","keywords":"Episodic memory; Dementia; Alzheimer's disease; Disease; Apolipoprotein E; Hippocampal formation; Memory clinic; Memory impairment; Hippocampus; Transcriptome; Cognition; Psychology; Neuroscience; Medicine; Biology; Genetics; Gene; Internal medicine; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003083451,0.0002399349,0.000364447,0.0005166272,0.0001920397,0.000368674,0.0002035017,0.0002270661,0.0009101238],"category_scores_gemma":[0.0004146648,0.0001261957,0.0004810805,0.0004408562,0.0001795831,0.00008099838,0.0003178568,0.0003189213,0.0001517586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001347379,"about_ca_system_score_gemma":0.0002009057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001578526,"about_ca_topic_score_gemma":0.002975256,"domain_scores_codex":[0.9998552,0.0000317091,0.000009125161,0.00005781454,0.0000250477,0.00002113424],"domain_scores_gemma":[0.9997805,0.00008151631,0.00006799034,0.00002506892,0.00001813246,0.00002691278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001741437,0.0001366488,0.09865724,0.0001080458,0.0005476899,0.001054542,0.0002745304,0.001755451,0.8828401,0.0003325297,0.000282737,0.01226899],"study_design_scores_gemma":[0.00008140664,0.000528575,0.9430918,0.00002288094,0.0007443331,0.00128706,0.0003041615,0.005578166,0.04598229,0.0006723379,0.001672816,0.0000342416],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968684,0.0001832085,0.001816809,0.00002630078,0.000006694274,0.000008181592,0.0008393216,0.00002531035,0.0002257846],"genre_scores_gemma":[0.995883,0.0001531573,0.002677757,0.00004080198,0.000004823521,0.00001731699,0.0008789432,0.0000259037,0.0003182357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001578526,"threshold_uncertainty_score":0.003138661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03971050085932205,"score_gpt":0.3066939233576769,"score_spread":0.2669834224983548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}