{"id":"W1481651785","doi":"10.3389/fgene.2015.00117","title":"Hippocampal transcriptome-guided genetic analysis of correlated episodic memory phenotypes in Alzheimer's disease","year":2015,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; U.S. National Library of Medicine; IXICO; Servier; Eisai; University of California, San Diego; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; Synarc; University of Southern California; Medpace; Novartis Pharmaceuticals Corporation; Dartmouth College; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Foundation for the National Institutes of Health; Alzheimer's Disease Neuroimaging Initiative; National Center for Advancing Translational Sciences; Meso Scale Diagnostics; Alzheimer's Association; National Science Foundation","keywords":"Episodic memory; Dementia; Alzheimer's disease; Disease; Apolipoprotein E; Hippocampal formation; Memory clinic; Memory impairment; Hippocampus; Transcriptome; Cognition; Psychology; Neuroscience; Medicine; Biology; Genetics; Gene; Internal medicine; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002321653,0.0002634436,0.0007583015,0.001226612,0.00002469454,0.00001194894,0.0001975432,0.0001342338,0.00006889227],"category_scores_gemma":[0.00008596858,0.0002514483,0.0002426109,0.001852776,0.0002351787,0.00004880424,0.00004094369,0.0002112998,0.0000152006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001866117,"about_ca_system_score_gemma":0.0006216574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001767637,"about_ca_topic_score_gemma":0.00005652845,"domain_scores_codex":[0.9975535,0.0001916711,0.0006174959,0.0004345402,0.000679067,0.0005236765],"domain_scores_gemma":[0.9982611,0.00003017578,0.0001072325,0.0005571159,0.0001719703,0.0008724016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001079826,0.0008581135,0.9671966,0.00003484122,0.0122591,0.0004783029,0.0006184955,0.008982709,0.00002204372,0.000002742582,0.002188686,0.006278561],"study_design_scores_gemma":[0.006437156,0.0003331734,0.9126803,0.00007993227,0.01309281,0.0000036869,0.0005764702,0.06550406,0.0003017986,0.0005963911,0.00009937381,0.0002948002],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8715511,0.1260096,0.0007895115,0.0001117053,0.000305834,0.0007128771,0.00008459658,0.00002751871,0.0004072646],"genre_scores_gemma":[0.9924412,0.001253638,0.00584866,0.00007891721,0.00003621445,0.00004852389,0.0002265169,0.00003811355,0.00002822174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1247559,"threshold_uncertainty_score":0.9999938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03971050085932205,"score_gpt":0.3066939233576769,"score_spread":0.2669834224983548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}