{"id":"W1481950324","doi":"10.1038/ncomms8075","title":"Degradation of Ndd1 by APC/CCdh1 generates a feed forward loop that times mitotic protein accumulation","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Azrieli Foundation; Israel Science Foundation; Israel Cancer Research Fund","keywords":"CDH1; Mitosis; Anaphase-promoting complex; Cell biology; CDC20; Biology; Chemistry; Anaphase; Ubiquitin; Ubiquitin ligase; Gene; Cell cycle; Genetics; Cell; Cadherin","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001440997,0.000339579,0.0002312355,0.0002074135,0.0002422398,0.0004468869,0.0003212953,0.0003261185,0.001899039],"category_scores_gemma":[0.0003237138,0.0002657748,0.0004397922,0.0001010991,0.0003326931,0.0003953243,0.0004063714,0.0003242621,0.0002515679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006399137,"about_ca_system_score_gemma":0.0004395326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001849807,"about_ca_topic_score_gemma":0.001141119,"domain_scores_codex":[0.9999338,0.000007575446,0.00000250782,0.00001634914,0.00002717418,0.00001254644],"domain_scores_gemma":[0.9999001,0.00002456326,0.00003620272,0.000009670041,0.00001691885,0.00001243605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003752503,0.0001288767,0.004316998,0.0003189148,0.00007152467,0.0005005334,0.0001077688,0.4663121,0.4712193,0.02949073,0.000552475,0.02660557],"study_design_scores_gemma":[0.00004626008,0.0001246073,0.002032256,0.000008827879,0.00002930567,0.0001372972,0.00001465278,0.9278663,0.06233183,0.005139205,0.00224753,0.00002193868],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5258766,0.0004208015,0.4593666,0.0004507306,0.00008036895,0.00006844138,0.0002375304,0.0006552649,0.01284351],"genre_scores_gemma":[0.9862208,0.0001261037,0.01020386,0.00002079089,0.000005981276,0.00003359036,0.00004488611,0.00001576455,0.003328177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001899039,"threshold_uncertainty_score":0.006352901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03153484868608877,"score_gpt":0.3028607928570446,"score_spread":0.2713259441709558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}