{"id":"W1481983812","doi":"10.1111/j.1462-5822.2010.01492.x","title":"Complement driven innate immune response to malaria: fuelling severe malarial diseases","year":2010,"lang":"en","type":"review","venue":"Cellular Microbiology","topic":"Malaria Research and Control","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Global Health Research; University Health Network","funders":"","keywords":"Innate immune system; Malaria; Immunology; Biology; Complement system; Severe Malaria; Immune system; Pathogenesis; Classical complement pathway; Inflammation; Alternative complement pathway; Antibody opsonization; Plasmodium falciparum; Opsonin; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.001026551,0.0008207252,0.003329029,0.0006391287,0.0002089376,0.00007211488,0.0007782314,0.001126334,0.002810363],"category_scores_gemma":[0.0005815559,0.0006565463,0.001080906,0.0003949276,0.0002217576,0.00003630817,0.0006544534,0.001935039,0.001751759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002661361,"about_ca_system_score_gemma":0.001305345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002633104,"about_ca_topic_score_gemma":0.00000951631,"domain_scores_codex":[0.994865,0.001372643,0.001217657,0.001104168,0.0001949073,0.00124565],"domain_scores_gemma":[0.9967905,0.0005280091,0.0003721459,0.001371016,0.000249383,0.0006890054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01015026,0.001110296,0.00003195804,0.01983559,0.00352572,0.004183788,0.0001485764,0.000002958059,0.5232626,0.003640143,0.00738676,0.4267214],"study_design_scores_gemma":[0.002364953,0.0005997129,0.00003181081,0.002744263,0.001641923,0.0006700833,0.00001134552,0.000004750095,0.0001666168,0.00003169258,0.9911312,0.0006016131],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002507717,0.9894965,0.0004316209,0.002593617,0.00125976,0.004493726,0.001199296,0.0001111344,0.0001636126],"genre_scores_gemma":[0.00134423,0.9835947,0.001069003,0.0004130781,0.001490792,0.000533745,0.006164073,0.0002049022,0.005185474],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9837445,"threshold_uncertainty_score":0.9995885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02576970766350802,"score_gpt":0.3088571901896809,"score_spread":0.2830874825261729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}