{"id":"W1482014066","doi":"10.1158/1538-7445.am2015-ct113","title":"Abstract CT113: A phase III, multicenter, randomized study evaluating the efficacy and safety and efficacy of erythrocyte encapsulated l-asparaginase (Ery001) versus native l-asparaginase (L-asp) in combination with COOPRALL regimen in patients with first relapse of acut","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pediatric Oncology Group","funders":"","keywords":"Tolerability; Medicine; Internal medicine; Adverse effect; Gastroenterology; Cmax; Regimen; Pharmacology; Pharmacokinetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001837067,0.002086549,0.003342648,0.000526151,0.0005564574,0.001424911,0.001307854,0.001502321,0.008239881],"category_scores_gemma":[0.00141859,0.0007223309,0.001767469,0.0007083265,0.00154429,0.0009546426,0.0005262031,0.005142138,0.001575176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001098035,"about_ca_system_score_gemma":0.002097182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001479102,"about_ca_topic_score_gemma":0.003268288,"domain_scores_codex":[0.9995306,0.0002611713,0.00002292341,0.00006562924,0.000039492,0.00008035237],"domain_scores_gemma":[0.9988841,0.0002061311,0.0002155385,0.00008180722,0.00005144355,0.0005609246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9356037,0.02173148,0.001955055,0.0005315756,0.0008184363,0.00009940365,0.00007597051,0.000618635,0.01558195,0.0001594967,0.001776366,0.02104795],"study_design_scores_gemma":[0.7841156,0.2104462,0.003041541,0.000029556,0.0002808699,0.00009079258,0.0000256671,0.0003875008,0.00092274,0.00007845867,0.0005666413,0.000014311],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896222,0.002011996,0.0005732769,0.000491217,0.0002722049,0.003309001,0.001630364,0.0001697406,0.001920147],"genre_scores_gemma":[0.9867894,0.001541819,0.001098232,0.0008011312,0.0003468364,0.003333094,0.002885503,0.00004482982,0.003159225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008239881,"threshold_uncertainty_score":0.02756518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0631438127890481,"score_gpt":0.4085930696162662,"score_spread":0.3454492568272182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}