{"id":"W1482347462","doi":"10.4049/jimmunol.0902725","title":"Predominant Expression of CCL2 at the Tumor Site of Prostate Cancer Patients Directs a Selective Loss of Immunological Tolerance to CCL2 That Could Be Amplified in a Beneficial Manner","year":2009,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Israel Science Foundation","keywords":"Prostate cancer; Chemokine; Cancer; Immune system; CCL2; Malignancy; Immunology; CCL5; Medicine; Disease; Prostate; Cancer research; Biology; IL-2 receptor; Pathology; Internal medicine; T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001440599,0.0002554116,0.0002490548,0.0002834412,0.0001778991,0.0004567169,0.0001118644,0.0001927296,0.002325996],"category_scores_gemma":[0.0001461586,0.00009310633,0.0001454655,0.0001747278,0.0003210935,0.0001347574,0.0001949138,0.0004771718,0.0002812084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002580514,"about_ca_system_score_gemma":0.0003637868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003933352,"about_ca_topic_score_gemma":0.0006755077,"domain_scores_codex":[0.9998065,0.00005187743,0.000008213949,0.0000348263,0.00003695359,0.00006164376],"domain_scores_gemma":[0.9998895,0.00001415591,0.00003629501,0.00001088008,0.00001334558,0.00003591889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002485051,0.00008131707,0.002345124,0.00009550421,0.000008652728,0.000163827,0.0000385521,0.00006454464,0.9921251,0.0001827751,0.0001306666,0.004515529],"study_design_scores_gemma":[0.0001338879,0.004350405,0.06231467,0.00004636682,0.00008850625,0.004113308,0.0002516547,0.001302622,0.9116201,0.0002830183,0.01547443,0.00002099473],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909436,0.003683649,0.002263051,0.0002282923,0.00004034275,0.0000413054,0.0001094878,0.00009384211,0.002596423],"genre_scores_gemma":[0.9980717,0.0004729468,0.0003891193,0.00006206074,0.00002241874,0.00001373302,0.0000682223,0.000005572612,0.0008942531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002325996,"threshold_uncertainty_score":0.007781208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01078639890518471,"score_gpt":0.2529288255317303,"score_spread":0.2421424266265456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}